Evidence map›Paper›PMID 40325454›Full record

ArticleBMC pulmonary medicine2025

Regional lung function assessment using electrical impedance tomography in COPD, PRISm, and normal spirometry subjects: insights into early diagnostic potential.

Jiayi Li, Zhanqi Zhao, Runze He, Yuhong Xie, Zhihao Xu, Chunwei Ni, Ting Jiang, Huiqing Ge

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In one paragraph

Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".International journal of chronic obstructive pulmonary disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayi LiZhejiang University, School of Medicine, Hangzhou, China.
Zhanqi ZhaoSchool of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China.
Runze HeZhejiang University, School of Medicine, Hangzhou, China.
Yuhong XieDepartment of Respiratory and Critical Care Medicine, the Fourth Affiliated Hospital of School of Medicine, Zhejiang University, Yiwu, China.
Zhihao XuDepartment of Respiratory and Critical Care Medicine, the Fourth Affiliated Hospital of School of Medicine, Zhejiang University, Yiwu, China.
Chunwei NiDepartment of Respiratory Therapy, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China.
Ting JiangTaizhou Hospital of Integrated Traditional Chinese and Western Medicine, Taizhou, China.
Huiqing GeDepartment of Respiratory Therapy, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China. gehq@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study utilizes electrical impedance tomography (EIT) to explore spatial-temporal heterogeneity in regional lung function among patients with chronic obstructive lung disease (COPD), preserved ratio impaired spirometry (PRISm), and those with normal lung function.

methodsSubjects who had pulmonary function test at Sir Run Run Shaw Hospital from 28 December 2023 to 30 March 2024 were screened. Regional lung functions were accessed with EIT regarding spatial distribution, abnormal area size, and expiratory time. The correlations between smoking index, SGRQ score, and EIT-related parameters were also evaluated.

resultsA total of 194 patients were screened and 161 patients were included (56 COPD, 21 PRISm, and 84 normal). Spatial distribution of regional FEV1EIT (P < 0.001), FVCEIT (P = 0.025), FEV1/FVCEIT (P < 0.001), MMEFEIT (P = 0.012), T-75EIT (P < 0.001), and FIVCEIT (P = 0.020) showed significant differences among the three groups. The percentage of abnormal FEV1/FVCEIT areas detected via EIT was 83.40% (25-75% percentiles 52.29%-98.39%) in the COPD group, 25.46% (17.31%-41.31%) in the PRISm group, and 10.37% (3.34%-19.04%) in the normal group. The time constant map revealed that the patients with COPD exhibited the longest exhalation times. Elevated smoking index and SGRQ scores were associated with increased heterogeneity and larger areas of abnormal FEV1/FVCEIT.

conclusionThrough EIT-based pulmonary function assessment, it is possible to sensitively identify the spatio-temporal heterogeneity in COPD and PRISm patients. Regional lung function impairments, particularly in PRISm patients with an FEV1/FVC ratio ≥ 0.7, were detected using EIT, highlighting its potential for early COPD diagnosis.

Indexed as

Electric ImpedanceLungPulmonary Disease, Chronic ObstructiveTomographyAgedEarly DiagnosisFemaleForced Expiratory VolumeHumansMaleMiddle AgedRespiratory Function TestsSpirometryVital CapacityChronic obstructive pulmonary diseaseElectrical impedance tomographyPreserved ratio impaired spirometryRegional lung function impairmentSpatial–temporal heterogeneity

Identifiers

PMID40325454
PMCPMC12051352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.