SynthesisBMC psychiatry2025
Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies.
Synthesis in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Healthy lifestyle and Alzheimer's disease in individuals with hyperlipidemia: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Prevention of cognitive decline and dementia: Current evidence on lifestyle factors and dietary patterns.EXCLI journal · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to assess the association between sedentary behavior (SB) and dementia among the general adult population.
methodsWe queried PubMed, Web of Science, Embase, and Cochrane Library from their inception to November 3, 2024. Two authors independently extracted the data from included studies, including hazard ratios (HRs) and their 95% confidence intervals (CIs), to assess the risk of dementia among individuals with SB. The quality of included studies was assessed using the Newcastle-Ottawa Scale. We used a random effects model if I
resultsWe included ten cohort studies, nine of which were of high quality. Our analysis demonstrated an increased risk of dementia among individuals with SB (pooled HRs, 1.17; 95% CIs, 1.06-1.29). Individuals with high sedentary time (ST), defined by TV viewing, demonstrated a 31% increased risk of dementia compared to those with low ST (pooled HRs, 1.31; 95% CIs, 1.25-1.37). No significantly increased risk for dementia was observed among individuals with high computer usage time (pooled HRs, 0.89; 95% CIs, 0.73-1.09). However, when SB was defined by other methods, individuals with high ST demonstrated a 33% increased risk of dementia compared to those with low ST (pooled HRs, 1.33; 95% CIs, 1.25-1.42).
conclusionSB increases the risk of dementia, but SB defined by computer usage time has not shown this association.
trial registrationCRD42023493109.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.