Evidence map›Paper›PMID 40325364›Full record

ArticleBMC genomics2025

Transcriptomic comparison analysis across seven developmental stages of the Triatoma rubrofasciata, a vector of Chagas disease.

Lei Duan, Yunjia Tian, Ziyi Wang, Limin Yang, Yunhai Guo, Yuanyuan Li, Zhengbin Zhou, Yong Shen, Yi Zhang, Qin Liu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lei Duan *NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Yunjia Tian *NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Ziyi Wang *NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Limin YangNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Yunhai GuoNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Yuanyuan LiNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Zhengbin ZhouNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Yong ShenNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Yi ZhangNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China.
Qin LiuNHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Center for International Research on Tropical Diseases, Shanghai, 200025, People's Republic of China. liuqin@nipd.chinacdc.cn.

Funding

National Key Research and Development Program of China No. 2021YFC2300800, No. 2021YFC2300803Three-Year Initiative Plan for Strengthening Public Health System Constructionn Shanghai (2023-2025) Key Discipline Project No. GWVI-11.1-12
6 · The paper itself

Abstract

backgroundTriatoma rubrofasciata is an obligate hematophagous insect and a primary vector of Trypanosoma cruzi, the etiological agent of Chagas disease, with a widespread global distribution. In addition to Try. cruzi, T. rubrofasciata also serves as a vector for various other pathogens, including Try. lewisi, Try. conorhini, and Bartonella species. Despite its increasing epidemiological relevance in the transmission of multiple diseases, research on T. rubrofasciata remains limited.

resultsDifferentially expressed genes (DEGs) were associated with growth, development, carbohydrate metabolism, and immunity. Notably, homeobox protein genes, including homeobox protein Nkx-6.2-like, homeobox protein abdominal-B isoform X1, homeobox protein Hox-A3-like, and Hox-B4-like, along with E3 ubiquitin protein ligase genes and sexual differentiation-related genes, such as male-specific lethal 1-like 1 isoform X3 (MSL), transformer-2 protein homolog beta-like isoform X2 (tra-2), and doublesex- and mab-3-related transcription factor A2-like (dsx), were highly expressed in the egg stage. Additionally, venom-related genes, including venom histidine phosphatase-like protein 1 and venom serine carboxypeptidase-like, were predominantly expressed in nymphal stages 4 and 5, while cytochrome P450 CYP425A1v2 exhibited high expression levels in the adult stages. Among these DEGs, we propose that homeobox protein genes, dsx, tra-2, and others may serve as candidate genes involved in growth, development, and sexual differentiation. This study provides valuable insights into gene expression dynamics during T. rubrofasciata development and establishes a foundation for future functional research on this species.

conclusionsIn this study, we sequenced the complete developmental stages of T. rubrofasciata using HiSeq technology. Our findings offer novel insights into the molecular mechanisms underlying development and sex regulation in this species. Furthermore, the identified differentially expressed genes (DEGs) may serve as potential targets for innovative pest control strategies.

Indexed as

Gene Expression ProfilingInsect VectorsTranscriptomeTriatomaAnimalsChagas DiseaseFemaleGene Expression Regulation, DevelopmentalInsect ProteinsMaleInsect ProteinsDifferential gene expression analysisNeglected tropical diseasesTriatominesT. rubrofasciata

Identifiers

PMID40325364
PMCPMC12051335

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