Evidence map›Paper›PMID 40325266›Full record

ArticleAnnals of biomedical engineering2025

Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics.

Kowsar Teimouri, Ahmed Darwish, Wael Saleh, Hoi Dick Ng, Lyes Kadem

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Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kowsar TeimouriLaboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada. kowsar.teimouri@concordia.ca.
Ahmed DarwishLaboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada.
Wael SalehLaboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada.
Hoi Dick NgLaboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada.
Lyes KademLaboratory of Cardiovascular Fluid Dynamics, Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC, Canada.

Funding

Natural Sciences and Engineering Research Council of Canada 343164-07
6 · The paper itself

Abstract

purposeThe MitraClip device has emerged as an effective treatment option for patients with mitral regurgitation. However, implementing a MitraClip alters the mitral valve structure and left ventricular flow dynamics. In this study, we experimentally investigate the effects of the MitraClip and the resulting twin pulsed jets on flow dynamics within the left ventricle.

methodsA custom-made left heart pulse duplicator was utilized, considering three different configurations: (1) a healthy mitral valve; (2) a regurgitant mitral valve; and (3) a repaired mitral valve with a MitraClip device. The flow field within the left ventricle was examined using time-resolved particle image velocimetry across different planes. Of particular interest was the analysis of flow structures, viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle.

resultsThe results indicate that mitral valve regurgitation increases both viscous energy dissipation and the accumulation of viscous shear stresses in the left ventricle along with a 45% increase in peak velocity compared to the case with a normal mitral valve. Moreover, while mitral valve repair with a MitraClip alters the flow dynamics in the left ventricle, generating twin pulsed jets, it effectively reduces viscous energy dissipation (by 25 and 36% in the lateral and side planes, respectively) and shear stress accumulation compared to the regurgitant valve. However, these improvements do not fully restore the levels observed in a healthy mitral valve.

conclusionMitraClip mitigates the adverse effects of mitral regurgitation by restoring key hemodynamic parameters closer to healthy levels, highlighting its potential as a promising treatment.

Indexed as

Heart VentriclesMitral ValveMitral Valve InsufficiencyModels, CardiovascularVentricular Function, LeftHumansFluid dynamicsLeft ventricleMitraClipMitral regurgitationParticle image velocimetry

Identifiers

PMID40325266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.