Evidence map›Paper›PMID 40325184›Full record

ArticleClinical neuroradiology2025

Hippocampal Subfield Vulnerability and Functional Connectivity in Cognitive Decline: a Comparison Between Parkinson's Disease and Mild Cognitive Impairment.

Na Wang, ChengLing Xu, XueLing Liu, SiRong Piao, Pu-Yeh Wu, LiQin Yang, XinYi Zhao, JiaJia Zhang, FengTao Liu, YuXin Li

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Clinical neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na WangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
ChengLing XuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
XueLing LiuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
SiRong PiaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Pu-Yeh WuGE Healthcare China, 100176, Beijing, China.
LiQin YangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
XinYi ZhaoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
JiaJia ZhangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FengTao LiuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China. liuft110@aliyun.com.
YuXin LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China. liyuxin@fudan.edu.cn.ORCID http://orcid.org/0000-0003-2107-6744

Funding

Key Projects of "Double First-Class" Initiative of Fudan University Grant No. XM03231648National Natural Science Foundation of China Grant No.82102132National Natural Science Foundation of China No. 82102016
6 · The paper itself

Abstract

purposeTo investigate the shared and distinct alterations in hippocampal subfield atrophy and functional connectivity (FC) in Parkinson's disease (PD) with normal cognition (PD-NC), PD with mild cognitive impairment (PD-MCI) and unspecified MCI (U-MCI).

methodsA total of 294 participants were included from two centers (30 PD-NC, 86 PD-MCI, 76 U-MCI, and 102 healthy controls (HC)). Comparisons of hippocampal subfield volumes were conducted among groups. Seed-based FC was calculated to assess abnormalities between hippocampal subfields and cortical regions.

resultsCompared to HC, PD-NC group showed volumetric reductions in the right cornu ammonis (CA) 2/3, granule cell layer of the dentate gyrus (GC-DG), and CA4 subfields, while PD-MCI group exhibited bilateral volumetric reductions in the same subfields. PD-MCI patients exhibited increased FC between the bilateral GC-DG/CA4 subfield and the posterior default mode network (pDMN), as well as between the right GC-DG/CA4 subfield and the calcarine, in comparison to PD-NC. U‑MCI patients displayed smaller volume in the right CA4 compared to HC. Decreased FC of the hippocampus with the widespread visual network was observed in the PD-MCI group compared to the U‑MCI group.

conclusionsPD-MCI is associated with structural vulnerability of hippocampal subfields in the CA2/3, GC-DG, and CA4 subfields, impacting FC with pDMN and visual network. Smaller scope of hippocampal subfields atrophy but weaker hippocampus-visual network FC abnormalities in U‑MCI relative to PD-MCI may suggest distinct progression mechanisms between these two conditions.

Indexed as

Cognitive DysfunctionHippocampusParkinson DiseaseAgedAtrophyCase-Control StudiesChinaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysNeuropsychological TestsRetrospective StudiesFunctional connectivityHippocampal subfieldMild cognitive impairmentParkinson’s disease

Identifiers

PMID40325184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.