Evidence map›Paper›PMID 40325144›Full record

ArticleNature chemistry2025

Leveraging relaxation-optimized

Andras Boeszoermenyi, Denitsa L Radeva, Sebastian Schindler, Veronica Valadares, Krishna M Padmanabha Das, Abhinav Dubey, Thibault Viennet, Max Schmitt, Peter Kast, Vladimir M Gelev and 17 more

Abstract read
In one paragraph

Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Biophysical journal · 2026
    Article
  2. Journal of molecular biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Andras BoeszoermenyiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. abandras912@gmail.com.ORCID 0000-0001-9810-7241
Denitsa L Radeva *Faculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria.
Sebastian Schindler *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0009-0008-6932-8203
Veronica ValadaresDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-1931-3464
Krishna M Padmanabha DasDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-0116-4256
Abhinav DubeyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-2392-8050
Thibault ViennetDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0001-5349-0179
Max SchmittLaboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland.ORCID 0009-0002-9328-7401
Peter KastLaboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-0209-8975
Vladimir M GelevFaculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria.ORCID 0000-0003-4309-6762
Nikolay StoyanovFaculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria.
Nikola BurdzhievFaculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria.
Ognyan PetrovFaculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria.
Scott FicarroDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jarred MartoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-2086-1134
Ezekiel A GeffkenDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sirano Dhe-PaganonDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hyuk-Soo SeoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0003-0646-2102
Nathan D AlexanderDepartment of Biochemistry and Biophysics, Oregon State University, GCE4All Research Center, Corvallis, OR, USA.ORCID 0009-0004-2551-6094
Richard B CooleyDepartment of Biochemistry and Biophysics, Oregon State University, GCE4All Research Center, Corvallis, OR, USA.
Ryan A MehlDepartment of Biochemistry and Biophysics, Oregon State University, GCE4All Research Center, Corvallis, OR, USA.
Helena KovacsBruker BioSpin, Fällanden, Switzerland.ORCID 0000-0002-5246-9439
Clemens AnklinBruker BioSpin, Billerica, MA, USA.ORCID 0000-0002-3421-8951
Wolfgang BermelBruker BioSpin, Rheinstetten, Germany.
Ilya KuprovSchool of Chemistry and Chemical Engineering, University of Southampton, Southampton, UK.ORCID 0000-0003-0430-2682
Koh TakeuchiGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. koh-takeuchi@mol.f.u-tokyo.ac.jp.ORCID 0000-0002-6227-4627
Haribabu ArthanariDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. hari@hms.harvard.edu.ORCID 0000-0002-7281-1289

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
Protein Production CoreP01AI143565 · NIAID · DANA-FARBER CANCER INST · PI Matthew J. Lang, ELLIS L REINHERZ · 2020 to 2026
$19.9M
The GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical ResearchRM1GM144227 · NIGMS · OREGON STATE UNIVERSITY · PI RYAN A MEHL · 2022 to 2026
$6.2M
NMR Fingerprinting: Leveraging optimal control pulse design, tailored isotope labeling, and machine learning to study intractable proteinsR01GM136859 · NIGMS · DANA-FARBER CANCER INST · PI ARTHANARI, HARIBABU · 2020 to 2024
$2.4M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI143565NIAID NIH HHS P01 AI143565NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM136859NIGMS NIH HHS RM1 GM144227NIH HHS S10 OD021527U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM124165U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM136859U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) RM1-GM144227
6 · The paper itself

Abstract

NMR spectroscopy of biomolecules provides atomic level information into their structure, dynamics and interactions with their binding partners. However, signal attenuation from line broadening caused by fast relaxation and signal overlap often limits the application of NMR to large macromolecular systems. Here we leverage the slow relaxation properties of

Indexed as

PhenylalanineProteinsCarbon IsotopesFluorineNuclear Magnetic Resonance, BiomolecularCarbon-13Carbon IsotopesFluorinePhenylalanineProteins

Identifiers

PMID40325144
PMCPMC12805932

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.