ArticleScientific reports2025
Association between triglyceride‑glucose index and lumbar bone mineral density among Chinese individuals with osteoporotic fractures: a cross sectional study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Long-term trajectories and cumulative exposure of the triglyceride-glucose-frailty index in relation to hip fracture risk: evidence from a large-scale population-based cohort.Archives of osteoporosis · 2026Article
- The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China.Journal of orthopaedic surgery and research · 2026Article
- An explainable predictive machine learning model of osteopenia for perimenopausal women based on clinical data: a retrospective single-center study.Frontiers in endocrinology · 2026Article
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8 authors.
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Abstract
Few studies have explored the association between the triglyceride-glucose (TyG) index and lumbar bone mineral density (BMD) across different skeletal sites in individuals with osteoporotic fractures (OPFs). The objective of this research was to investigate the relationship between the TyG index and lumbar BMD in individuals with OPFs. Conducted at the Affiliated Kunshan Hospital of Jiangsu University between January 2017 and March 2024, this retrospective cross-sectional study involved 950 OPFs patients requiring hospitalization or surgery. In this study, lumbar BMD the dependent variable, while the TyG index served as the independent variable. Generalized estimating equations (GEE) were used to evaluate the association between the TyG index and lumbar BMD levels. The generalized additive model (GAM) was employed to explore non-linear associations. In the all-adjusted models, a positive association was found between the TyG index and lumbar BMD among the patients with OPFs (β = 0.027; 95% confidence interval [CI] 0.011-0.042; P-value < 0.001). Similar results were observed across the four quantiles of the TyG index, Q4 (β = 0.045; 95% confidence interval [CI] 0.019-0.072; P-value < 0.001). A highly uniform pattern was noted across these findings. The evidence-based discovery of the relationship between the TyG index and lumbar BMD could inform clinical practices, particularly in the assessment and management of bone health in patients with OPFs.
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