Evidence map›Paper›PMID 40325063›Full record

Observational studyScientific reports2025

Frequency, intensity and duration of physical activity is associated with frailty in older adults with cardiac aging.

Laureen Y T Wang, Wee Shiong Lim, Ru-San Tan, Louis L Y Teo, Shu Yun Tan, Chun How Ooi, Alvin Cong Wei Ong, Jean-Paul Kovalik, Jorming Goh, Fei Gao and 1 more

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laureen Y T WangAlexandra Hospital, National University Health System, Singapore, Singapore.
Wee Shiong LimInstitute of Geriatrics and Active Aging, Tan Tock Seng Hospital, Singapore, Singapore.
Ru-San TanNational Heart Centre Singapore, Singapore, Singapore.
Louis L Y TeoNational Heart Centre Singapore, Singapore, Singapore.
Shu Yun TanNational Healthcare Group Polyclinics, Singapore, Singapore.
Chun How OoiChangi General Hospital, Singapore, Singapore.
Alvin Cong Wei OngJurong Community Hospital, Singapore, Singapore.
Jean-Paul KovalikDuke-NUS Medical School, Singapore, Singapore.
Jorming GohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore.
Fei GaoNational Heart Centre Singapore, Singapore, Singapore.
Angela S KohNational Heart Centre Singapore, Singapore, Singapore. gmsksma@nus.edu.sg.

Funding

National Medical Research Council MOH-001200
6 · The paper itself

Abstract

While cardiovascular aging and frailty are strongly associated in older adults, their mechanistic relationship and how physical activity, through its frequency, intensity, and duration, may influence their association remains unclear. A prospective community cohort of older adults without cardiovascular disease were studied cross-sectionally for cardiac structure and function via echocardiogram, dynamometer-derived handgrip strength, skeletal muscle measurements and physical activity questionnaires. Based on handgrip strength and cardiac aging, we derived four phenotypic groups:

Indexed as

AgingExerciseFrailtyHeartAgedAged, 80 and overCross-Sectional StudiesFemaleFrail ElderlyHand StrengthHumansMaleMiddle AgedProspective StudiesRisk FactorsCardiovascular agingFrailtyPhysical activityPreventive cardiology

Identifiers

PMID40325063
PMCPMC12053682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.