Evidence map›Paper›PMID 40325051›Full record

ArticleScientific reports2025

Anti-diabetes activity of (R)-gentiandiol in KKAy type 2 mice.

Yaqi Xu, Jinyue Huang, Shuhan Tang, Yidan Sun, Hao Li, Pengyu Li, Xianna Li, Masao Hattori, Xiuhong Wu, Hailong Zhang and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Therapeutic Potential ofBiomedicines · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaqi XuDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Jinyue HuangDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Shuhan TangInstitute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Yidan SunDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Hao LiDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Pengyu LiDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Xianna LiDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Masao HattoriInstitute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Xiuhong WuDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China.
Hailong ZhangSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Zhigang WangDepartment of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin, 150040, China. wangzhigang0513@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Swertiamarin is a major component of many traditional Chinese Swertia herbs that show significant antidiabetic activity. (R)-Gentiandiol and (S)-gentiandiol are metabolites of swertiamarin found in vivo. The antidiabetic activity of swertiamarin and its nitrogen-containing metabolites (R)-gentiandiol and (S)-gentiandiol was evaluated in this research, and their mechanism of action was investigated after evaluating the serum metabolic profile of KK/Upj-A

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Hypoglycemic AgentsIridoid GlucosidesPyronesAnimalsKidneyMaleMetabolomicsMicePancreasHypoglycemic AgentsIridoid GlucosidesPyronesswertiamarin(R)-GentiandiolSwertiamarinType 2 diabetes mellitus

Identifiers

PMID40325051
PMCPMC12052974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.