TMS-EEG evidence links random exploration to inhibitory mechanisms in the dorsolateral prefrontal cortex.

Adaptive decision-making in uncertain environments requires balancing exploration and exploitation. Computational models distinguish between directed exploration, involving deliberate information-seeking, and random exploration, characterized by stochastic variability. The neural correlates of these strategies have been investigated in previous studies. However, while prior research implicates the dorsolateral prefrontal cortex (DLPFC) in random exploration, its underlying excitatory and inhibitory mechanisms remain unclear. Understanding these processes is essential for explaining how individuals adapt to a dynamic environment. To investigate this, we combined transcranial magnetic stimulation (TMS) with electroencephalography (EEG) to directly assess cortical excitatory and inhibitory functions. Twenty-five healthy participants completed the Horizon Task, a behavioral paradigm designed to dissociate directed and random exploration, and after the task, they received single-pulse TMS over the DLPFC. The TMS-evoked potentials (TEPs) N45, P60, and N100 were examined as neurophysiological markers of GABA