ArticleNature communications2025
Health octo tool matches personalized health with rate of aging.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults.The journal of prevention of Alzheimer's disease · 2026Article
- Genomic Perspective on Heterogeneity of Organs and Body Aging.Aging cell · 2026Review
- Nurses as guardians of time: the hidden clinical value of continuous care in geriatrics.Frontiers in public health · 2026Review
- Multimorbidity quantification from the perspective of precision management: challenges and strategies.Annals of medicine · 2025Review
- Health octo tool matches personalized health with rate of aging.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Medical practice mainly addresses single diseases, neglecting multimorbidity as a heterogeneous health decline across organ systems. Aging is a multidimensional process and cannot be captured by a single metric. Therefore, we assessed global health in longitudinal studies, BLSA (n = 907), InCHIANTI (n = 986), and NHANES (n = 40,790), by examining disease severities in 13 bodily systems, generating the Body Organ Disease Number (BODN), reflecting progressive system morbidities. We used Bayesian ordinal models, regressing BODN over organ specific and all organs disease severities to obtain Body System-Specific Clocks and the Body Clock, respectively. The Body Clock is BODN weighted by the posterior coefficient of diseases for each individual. It supersedes the frailty index, predicting disability, geriatric syndrome, SPPB, and mortality with ≥90% accuracy. The Health Octo Tool, derived from Bodily System-Specific Clocks, the Body Clock and Clocks that incorporate walking speed and disability and their aging rates, captures multidimensional aging heterogeneity across organs and individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.