ArticleLight, science & applications2025
MINFLUX nanoscopy enhanced with high-order vortex beams.
Article in Light, science & applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors.
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Abstract
Minimal photon fluxes (MINFLUX) nanoscopy has emerged as a transformative advancement in superresolution imaging, enabling unprecedented nanoscale observations across diverse biological scenarios. In this work, we propose, for the first time, that employing high-order vortex beams can significantly enhance the performance of MINFLUX, surpassing the limitations of the conventional MINFLUX using the first-order vortex beam. Our theoretical analysis indicates that, for standard MINFLUX, high-order vortex beams can improve the maximum localization precision by a factor corresponding to their order, which can approach a sub-nanometer scale under optimal conditions, and for raster scan MINFLUX, high-order vortex beams allow for a wider field of view while maintaining enhanced precision. These findings underscore the potential of high-order vortex beams to elevate the performance of MINFLUX, paving the way towards ultra-high resolution imaging for a broad range of applications.
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Registered trials
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