ArticleAmerican journal of nephrology2025
Association between Rheumatoid Arthritis and the Incidence of IgA Nephropathy.
Article in American journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Dilemma of missing specific disease codes: an approach to assess the incidence and prevalence of a rare nephrology disease.BMC nephrology · 2025Observational
- Biomarker understanding first lessons from drug development for IgA-driven autoimmune and fibrotic diseases.Cambridge prisms. Precision medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
<p>Introduction: IgA nephropathy and rheumatoid arthritis are both common autoimmune diseases, but epidemiological data are limited on the relationship between these two diseases. We aimed to assess the association between rheumatoid arthritis and the risk of developing IgA nephropathy.
methodsIn this study, we analyzed 4,311,393 adults using a nationwide epidemiological database in Japan. The definitions of rheumatoid arthritis and IgA nephropathy were based on ICD-10 codes. After excluding individuals with a prior history of IgA nephropathy, study participants were categorized into two groups according to the presence of rheumatoid arthritis. The primary outcome was the incidence of IgA nephropathy between January 2005 and May 2022.
resultsMedian (interquartile range) age was 44 (36-53) years, and 2,497,313 (58%) were men. Rheumatoid arthritis was observed in 41,828 individuals (1.0%). During a median follow-up of 1,089 (532-1,797) days, there were 2,610 and 43 incidences of IgA nephropathy in individuals without and with rheumatoid arthritis, yielding incidence rates with 95% confidence intervals (CIs) of 1.74 (1.67-1.81) and 2.99 (2.22-4.04) per 10,000 person-years, respectively, indicating a higher cumulative incidence in individuals with rheumatoid arthritis (log-rank p = 0.0002). Multivariable Cox regression analysis demonstrated that comorbid rheumatoid arthritis had a higher risk for developing IgA nephropathy (hazard ratio (HR) 1.50, 95% CI 1.10-2.02). Results were consistent even when IgA nephropathy was defined as both the ICD-10 code with the confirmation of performance of kidney biopsy (HR 1.70, 95% CI 1.02-2.83).
conclusionOur analysis utilizing a large-scale population-based cohort concluded that rheumatoid arthritis may increase risk of developing IgA nephropathy. </p>.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.