Evidence map›Paper›PMID 40324196›Full record

ArticleAnnals of internal medicine2025

Diet and Risk for Incident Diverticulitis in Women : A Prospective Cohort Study.

Trevor Barlowe, Chelsea Anderson, Hazel B Nichols, Anna C Salvador, Robert S Sandler, Dale P Sandler, Anne F Peery

Abstract read
In one paragraph

Article in Annals of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Trevor BarloweCenter for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.B., C.A., A.C.S., R.S.S., A.F.P.).
Chelsea AndersonCenter for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.B., C.A., A.C.S., R.S.S., A.F.P.).ORCID 0000-0001-6535-481X
Hazel B NicholsDepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (H.B.N.).ORCID 0000-0003-0972-1560
Anna C SalvadorCenter for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.B., C.A., A.C.S., R.S.S., A.F.P.).
Robert S SandlerCenter for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.B., C.A., A.C.S., R.S.S., A.F.P.).
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (D.P.S.).ORCID 0000-0002-6776-0018
Anne F PeeryCenter for Gastrointestinal Biology and Disease, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (T.B., C.A., A.C.S., R.S.S., A.F.P.).ORCID 0000-0002-2005-0780

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
DIGESTIVE DISEASES EPIDEMIOLOGY TRAINING PROGRAMT32DK007634 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1990 to 2026
$7.4M
A prospective cohort study to determine the role of obesity in diverticulitisR01DK132050 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI anne peery · 2022 to 2026
$2.8M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 ES044005NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R01 DK132050NIDDK NIH HHS T32 DK007634
6 · The paper itself

Abstract

backgroundPatients with diverticulitis often attempt to control their diet with a particular focus on avoiding nuts and seeds. However, whether dietary patterns or dietary intake of nuts and seeds are associated with diverticulitis risk is poorly studied, particularly in women.

objectiveTo determine whether select diets affect incident diverticulitis risk in women.

designProspective cohort study.

settingCohort study in the United States and Puerto Rico.

participantsWomen aged 35 to 74 years at enrollment who responded to food frequency and diverticulitis questionnaires and had no history of inflammatory bowel disease, cancer, or diverticulitis (

interventionFood frequency questionnaires were used to calculate dietary index scores and to assess intake of nuts, seeds, and corn. MEASUREMENTS: Cox proportional hazards regression was used to estimate adjusted hazard ratios (aHRs) and 95% CIs for the associations between each dietary component or dietary index and diverticulitis risk.

results1531 cases of incident diverticulitis for 415 103 person-years of follow-up were identified. Intake of peanuts, nuts, and seeds (aHR,1.07 [95% CI, 0.91 to 1.25]) and fresh fruits with edible seeds (aHR,1.06 [CI, 0.90 to 1.24]) was not associated with incident diverticulitis. There was a reduced risk for incident diverticulitis in women in the highest quartile of healthy diets compared with the lowest quartile: the Dietary Approaches to Stop Hypertension diet (aHR, 0.77 [CI, 0.65 to 0.90]), the Healthy Eating Index (aHR, 0.78 [CI, 0.66 to 0.91]), the Alternative Healthy Eating Index (aHR, 0.81 [CI, 0.69 to 0.95]), and the Alternative Mediterranean diet (aHR, 0.91 [CI, 0.78 to 1.06]). LIMITATION: Confounding, selection bias, and measurement bias are possible.

conclusionHealthy diets were associated with a reduced risk for incident diverticulitis in women. Consumption of nuts and seeds was not associated with diverticulitis risk. PRIMARY FUNDING SOURCE: National Institutes of Health.

Indexed as

DietDiverticulitisAdultAgedFemaleHumansIncidenceMiddle AgedNutsProportional Hazards ModelsProspective StudiesPuerto RicoRisk FactorsUnited States

Identifiers

PMID40324196
PMCPMC12331370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.