Evidence map›Paper›PMID 40324067›Full record

Trial reportBehavioral sleep medicine

Prevention of Pain Interference in Insomnia Patients via Digital Cognitive-Behavioral Therapy for Insomnia.

Matthew B Jennings, David A Kalmbach, Anthony N Reffi, Christopher B Miller, Timothy Roehrs, Christopher L Drake, Philip Cheng

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Behavioral sleep medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew B JenningsSleep Disorders and Research Center, Henry Ford Health, Detroit, MI, USA.ORCID 0009-0009-3798-6022
David A KalmbachSleep Disorders and Research Center, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0003-3107-0522
Anthony N ReffiSleep Disorders and Research Center, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0002-2783-1678
Christopher B MillerBig Health Inc., San Francisco, USA.ORCID 0000-0002-2936-7717
Timothy RoehrsSleep Disorders and Research Center, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0001-9237-0153
Christopher L DrakeSleep Disorders and Research Center, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0002-5486-3587
Philip ChengSleep Disorders and Research Center, Henry Ford Health, Detroit, MI, USA.ORCID 0000-0002-2874-658X

Funding

Enhancing digital CBT-I to improve adherence and reduce disparitiesR01HL159180 · NHLBI · HENRY FORD HEALTH SYSTEM · PI CHENG, PHILIP · 2021 to 2025
$3.0M
Sleep to Reduce Incident Depression Effectively (STRIDE)R01MH122636 · NIMH · HENRY FORD HEALTH SYSTEM · PI DRAKE, CHRISTOPHER L · 2020 to 2022
$1.8M
Identifying sleep-related risk factors for PTSD and their underlying mechanismsK23MH134032 · NIMH · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Anthony Reffi · 2024 to 2026
$435k
NHLBI NIH HHS R01 HL159180NIMH NIH HHS K23 MH134032NIMH NIH HHS L30 MH137828NIMH NIH HHS R01 MH122636
6 · The paper itself

Abstract

objectivesInsomnia disorder is co-morbid with and predictive of developing pain conditions and a key factor in pain interference (PI) - the extent to which pain impedes daily living. Emerging literature suggests treating insomnia with cognitive-behavioral therapy for insomnia reduces co-occurring PI. This secondary data analysis tested the extent to which digital CBT-I (dCBT-I) vs. sleep education reduces and prevents significant PI by treating insomnia.

methodsInsomnia disorder participants were randomized into dCBT-I (

resultsThe reduction model showed that dCBT-I participants with moderate-to-severe pre-treatment PI experienced 17% odds increase in reduced PI for each one-point reduction in insomnia severity compared to control, OR = 1.17, 95% CI [1.01, 1.35]. In the prevention model, dCBT-I participants with little-to-no pre-treatment PI exhibited a 32% odds reduction of post-treatment progression to moderate-to-severe PI compared to control, OR = 0.68, 95% CI [0.51, 0.90].

conclusiondCBT-I demonstrated significant and clinically meaningful reduction and prevention effects against PI in a large sample. dCBT-I may help providers address sleep issues to restore pain-related impairments to daytime function, quality of life, and overall sleep.

Indexed as

Cognitive Behavioral TherapyPainPain ManagementSleep Initiation and Maintenance DisordersAdultFemaleHumansMaleMiddle AgedTreatment Outcome

Identifiers

PMID40324067
PMCPMC12266104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.