ArticlePloS one2025
Global burden of ischemic stroke in adults aged 60 years and older from 1990 to 2021: Population-based study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- AI home monitoring for behavioral markers of cerebrovascular disease.NPJ digital medicine · 2026Article
- Serum and Striatal Redox and Metabolic Responses to Progesterone Treatment in Rats with Common Carotid Ligation.Antioxidants (Basel, Switzerland) · 2026Article
- CCR1 as a potential regulator of neutrophil-mediated pathogenesis in post-acute ischemic stroke: a multi-omics Mendelian randomization.Clinical epigenetics · 2026Article
- Association between METS-IR and incident stroke in a nationwide prospective cohort of non-diabetic Chinese adults.BMC neurology · 2026Article
- Article
- Latent profiles of future care preparation among older adults with stroke and associations with filial responsibility expectations.Frontiers in public health · 2026Article
- Predictive value of contrast-enhanced ultrasound in assessing the risk of recurrent in ipsilateral anterior circulation ischemic stroke.BMC medical imaging · 2025Article
- Beyond visual inspection: the deep learning revolution in quantitative cerebrovascular imaging.Frontiers in neuroscience · 2025Review
- Global, regional, and national burden of disease for high BMI-related ischemic stroke in people aged 70 and older: trend analysis from 1990 to 2021 and projections for 2044.Frontiers in neurologyArticle
- Machine learning-based prediction of cerebral artery territorial infarcts in acute ischemic stroke using non-contrast CT.Frontiers in neurologyArticle
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7 authors.
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Abstract
backgroundIschemic stroke is an important public health problem. However, comprehensive data on its burden in aging populations is limited. The aim of this study is to provide an up-to-date assessment of the prevalence, incidence, mortality, disability-adjusted life years, and risk factors for ischemic stroke globally in adults aged 60 years and older from 1990 to 2021 based on population changes.
methodsThe Global Burden of Diseases, Injuries, and Risk Factors Study 2021 served as the data source for this study. Average annual percentage changes were estimated over the study period to quantify temporal patterns and assess trends in age-standardized rates of the prevalence, incidence, mortality, and disability-adjusted life-years of ischemic stroke.
resultsThe significant increase in the prevalence and incidence of ischemic stroke is mainly related to population ageing and the significant increase in the number of people over 60 years of age, with the significant increase in the population over 60 years of age being the main driving force, while epidemiological changes have had the opposite effect. Critically, using the entire age population for calculations will prompt us to underestimate the burden of ischemic stroke. The burden of ischemic stroke disease is highest in older men than in older women, and the age-standardized prevalence rates, incidence rates, mortality rates, and disability-adjusted life-years rates are 26-35% higher in men than in women. High-middle sociodemographic index and Sub-Saharan Africa regions suffer the heaviest burden. Ischemic stroke health inequities widen, with less developed regions bearing a heavier ischemic stroke burden and the disparity in that burden becoming more pronounced over time.
conclusionPopulation aging is the primary driver of the growing burden of ischemic stroke. Our findings indicate that prevention and control of this disease remain critical public health challenges. Targeted interventions addressing modifiable risk factors could significantly reduce the global burden of ischemic stroke.
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