Evidence map›Paper›PMID 40323951›Full record

ArticlePloS one2025

Histological study of donor/recipient feasibility in distal nerve transfer for the upper limb nerve injury.

Akira Kodama, Atsushi Kunisaki, Teruyasu Tanaka, Shigeki Ishibashi, Kentarou Tsuji, Masaru Munemori, Goki Kamei, Koji Ikegami, Nobuo Adachi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akira KodamaDivision of Regenerative Medicine for Musculoskeletal System Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.ORCID 0000-0002-1066-7015
Atsushi KunisakiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Teruyasu TanakaDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shigeki IshibashiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0003-1276-4879
Kentarou TsujiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Masaru MunemoriDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Goki KameiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Koji IkegamiDepartment of Anatomy and Developmental Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Nobuo AdachiDepartment of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to histologically investigate whether the compatibility of donor and recipient nerves in distal nerve transfer for radial and ulnar nerve palsy is suitable for restoring nerve function. Partial median to radial nerve transfer for radial nerve palsy and partial median to ulnar nerve transfer for ulnar nerve palsy were performed in 10 cadaveric upper limbs fixed using the Thiel technique. Histological analysis of the nerve samples at the coaptation site focused on the number of myelinated axons. Each recipient and donor nerve was identified in all specimens without any anatomical variations. While median-radial nerve transfer techniques showed an adequate number of donor axons, median-ulnar nerve transfer techniques showed a shortage of donor axons. The insufficiency of donor axons compared to the recipient axons may explain the challenges in reinnervating the recipient muscles. Combining the two different nerve transfers may compensate for the shortage of donor axons and improve motor recovery. Type of study and Level of evidence: Therapeutic, Level III.

Indexed as

Median NerveNerve TransferRadial NerveUlnar NerveUpper ExtremityAgedAxonsCadaverFeasibility StudiesFemaleHumansMaleMiddle Aged

Identifiers

PMID40323951
PMCPMC12052152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.