ArticlePloS one2025
Inhibition of xpt Guanine Riboswitch by a synthetic nucleoside analog.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Riboswitches are structured elements predominantly found in the 5'-untranslated region of many bacterial mRNA. These noncoding RNA regions play a vital role in bacterial metabolism and overall function. Each riboswitch binds to a specific small molecule and causes conformational changes in the mRNA leading to regulation of transcription or translation. In this work, we have synthesized SK4, a novel nucleoside analog that binds to the guanine riboswitch mRNA of the xanthine phosphoribosyl transferase gene in Bacillus subtilis and terminates transcription of the riboswitch mRNA to a greater extent than the native ligand guanine. Molecular dynamics simulations of SK4 with riboswitch mRNA reveal an overall stable complex with additional bonding interactions in comparison to guanine. Our work with SK4 demonstrates that specific genes in bacteria can be effectively controlled by ligand analogs, providing an alternative mechanism to regulate the function of bacteria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.