ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2025
Socioeconomic status, prefrontal cortical volume, and cardiometabolic risk in early adolescence.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveYouth from socioeconomically disadvantaged families are disproportionately at risk for developing cardiometabolic diseases. Underlying mechanisms, however, remain unclear. Therefore, we examined whether socioeconomic disadvantage was associated with structural variations in regions that underlie emotion processing and executive control, and whether those variations were in turn associated with cardiometabolic risk during adolescence. Primary areas of interest included the dorsolateral prefrontal (dlPFC) and orbitofrontal cortex (OFC), and secondary areas included the ventrolateral prefrontal cortex, amygdala, and hippocampus in sensitivity analyses.
methodParticipants were 277 racially and ethnically diverse adolescents (
resultsLower parent education was associated with smaller dlPFC volume, lateral OFC volume, and cardiometabolic risk at Time 1. Additionally, lower parent education and smaller dlPFC volume predicted greater cardiometabolic risk 2 years later at Time 2. Path analyses indicated that smaller dlPFC volume accounted for the association between parent education and cardiometabolic risk cross-sectionally and longitudinally 2 years later, but not for prospective changes in cardiometabolic risk.
conclusionFindings suggest that structural variation in the dlPFC may be a pathway connecting parent education to later cardiometabolic health problems. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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