ArticleThe Journal of organic chemistry2025
Bichromophoric Ruthenium Complexes for Photocatalyzed Late-Stage Synthesis of Trifluoromethylated Indolizines.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- C-C Bond Formation via Direct Functionalization of Indolizines with a Bichromophoric Ruthenium Photocatalyst.ACS organic & inorganic Au · 2026Article
- Trifluoromethyl Thianthrenium Salts: From Organic Synthesis to Materials.The Journal of organic chemistry · 2026Review
- Access to SCFOrganic letters · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indolizines are a promising class of biologically active compounds. However, photocatalytic methods for their selective derivatization are scarce in the literature. Herein, a mild, simple, and chemoselective protocol for the synthesis of 3-(trifluoromethyl)indolizine has been developed. The desired products were obtained in good to excellent yields and can be easily obtained on a gram scale. By tuning the redox properties of a Ru-based photocatalyst, it is possible to achieve competitive yields and further apply the optimized conditions to a broad variety of substrates. This method tolerates many functional groups and, therefore, can be used for late-stage functionalization. Our combined theoretical and spectroscopic findings revealed that the superior dyad-like ruthenium catalyst developed in this study has a completely different electronic nature of both key species that are crucial for efficient photoredox catalysis compared to commonly used homoleptic ruthenium complexes.
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Registered trials
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