Evidence map›Paper›PMID 40323694›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF-β/Smad2/3 Signaling in Mice.

Mantong Zhao, Lina Hu, Zhuo Lin, Xueling Yue, Xintong Zheng, Meiling Piao, Xianglan Jin, Limei Piao, Rihua Cui, Meilan Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. CD8FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Increased Dipeptidyl Peptidase-4 Promotes Adipose Inflammation and Dysfunction in Mice Under Chronic Stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Frontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mantong ZhaoDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Lina HuDepartment of Public Health, Guilin Medical College, Guilin, Guangxi, P.R. China.
Zhuo LinDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Xueling YueDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Xintong ZhengDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Meiling PiaoDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Xianglan JinDepartment of Anesthesiology, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Limei PiaoDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Rihua CuiDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Meilan LiuDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.
Xian Wu ChengDepartment of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease, Yanbian University Hospital, Yanji, Jilin, P.R. China.ORCID https://orcid.org/0000-0002-9758-0632

Funding

MOST | National Natural Science Foundation of China (NSFC) 81560240MOST | National Natural Science Foundation of China (NSFC) 81770485MOST | National Natural Science Foundation of China (NSFC) 82160103MOST | National Natural Science Foundation of China (NSFC) 82260091MOST | National Natural Science Foundation of China (NSFC) 82370424
6 · The paper itself

Abstract

Given that plasminogen activator inhibitor 1 (PAI-1) plays an important role in human pathobiology and epigallocatechin-3-gallate (EGCG) exerts vasculoprotective actions, we investigated the role(s) of PAI-1 and the protective effect of EGCG in the mechanism of AAA formation, with a focus on inflammation, oxidative stress, proteolysis, and apoptosis in vivo and in vitro. Nine-week-old wild-type mice (PAI-1

Indexed as

Aortic Aneurysm, AbdominalPlasminogen Activator Inhibitor 1Serpin E2Signal TransductionSmad2 ProteinSmad3 ProteinTransforming Growth Factor betaAnimalsApoptosisCatechinMaleMiceMice, Inbred C57BLMice, KnockoutOxidative StressCatechinepigallocatechin gallatePlasminogen Activator Inhibitor 1Serpin E2Serpine2 protein, mouseSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseTransforming Growth Factor betaabdominal aortic aneurysmapoptosisepigallocatechin‐3‐gallateinflammationoxidative stressplasminogen activator inhibitor 1

Identifiers

PMID40323694
PMCPMC12051826

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.