Evidence map›Paper›PMID 40323550›Full record

ArticleAnnals of surgical oncology2025

Impact of Anatomical Resection on Non-transplantable Recurrence Among Patients with Hepatocellular Carcinoma: An International Multicenter Inverse Probability of Treatment Weighting Analysis.

Jun Kawashima, Yutaka Endo, Mujtaba Khalil, Selamawit Woldesenbet, Miho Akabane, Andrea Ruzzenente, Francesca Ratti, Hugo Marques, Sara Oliveira, Jorge Balaia and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jun KawashimaDepartment of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.
Yutaka EndoDepartment of Transplant Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Mujtaba KhalilDepartment of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.
Selamawit WoldesenbetDepartment of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.
Miho AkabaneDepartment of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA.
Andrea RuzzenenteDepartment of Surgery, University of Verona, Verona, Italy.
Francesca RattiDepartment of Surgery, San Raffaele Hospital, Milan, Italy.
Hugo MarquesDepartment of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
Sara OliveiraDepartment of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
Jorge BalaiaDepartment of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
François CauchyDepartment of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.
Vincent LamDepartment of Surgery, Westmead Hospital, Westmead, NSW, Australia.
George PoultsidesDepartment of Surgery, Stanford University, Stanford, CA, USA.
Minoru KitagoDepartment of Surgery, Keio University, Tokyo, Japan.
Irinel PopescuDepartment of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
Guillaume MartelDepartment of Surgery, University of Ottawa, Ottawa, ON, Canada.
Ana GleisnerDepartment of Surgery, University of Colorado Denver, Denver, CO, USA.
Thomas J HughDepartment of Surgery, The University of Sydney, Sydney, NSW, Australia.
Luca AldrighettiDepartment of Surgery, San Raffaele Hospital, Milan, Italy.
Itaru EndoDepartment of Gastroenterological Surgery, Yokohama City University, Yokohama, Japan.
Timothy M PawlikDepartment of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH, USA. Tim.Pawlik@osumc.ed.ORCID http://orcid.org/0000-0002-7994-9870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong patients with hepatocellular carcinoma (HCC), the impact of anatomic resection (AR) versus non-anatomic resection (NAR) on non-transplantable recurrence (NTR) remains poorly defined. We sought to compare the risk of NTR among patients treated with AR versus NAR as the primary surgical strategy for HCC. PATIENTS AND

methodsPatients with HCC within Milan criteria who underwent curative-intent resection between 2000 and 2020 were identified from an international multi-institutional database. The inverse probability of treatment weighting (IPTW) method was utilized to compare short- and long-term outcomes among patients undergoing AR versus NAR.

resultsAmong 1038 patients, 747 (72.0%) patients underwent AR, while 291 (28.0%) patients underwent NAR. After IPTW adjustment, patients who underwent AR had better 5-year recurrence-free survival than individuals treated with NAR (63.9 vs. 52.0%; hazard ratio [HR] 0.78; 95% confidence interval [CI] 0.62-0.99); however, there was no difference in 5-year overall survival (80.2 vs. 75.6%; HR 0.76; 95% CI 0.55-1.05). Notably, individuals who underwent AR were less likely to have a NTR versus individuals treated with NAR (3-year NTR 9.8 vs. 14.4%; HR 0.62; 95% CI 0.40-0.96). In particular, AR was associated with a lower risk of NTR among patients with a medium tumor burden score (TBS) (HR 0.53; 95% CI 0.28-0.99), while the benefit among patients with a low TBS was less pronounced (HR 0.73; 95% CI 0.40-1.32).

conclusionsAR was associated with a lower risk of NTR and improved recurrence-free survival (RFS) among patients with HCC, especially individuals with higher TBS. An anatomically defined surgical approach should be strongly considered in patients with a higher HCC tumor burden.

Indexed as

Carcinoma, HepatocellularHepatectomyLiver NeoplasmsNeoplasm Recurrence, LocalAgedFemaleFollow-Up StudiesHumansLiver TransplantationMaleMiddle AgedPrognosisRetrospective StudiesSurvival Rate

Identifiers

PMID40323550
PMCPMC12317867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.