Evidence map›Paper›PMID 40323545›Full record

ReviewDermatology and therapy2025

Local Corticosteroids for Alopecia Areata: A Narrative Review.

Samantha Gregoire, Basil McIntosh, Katherine Sanchez, Ursula Biba, Arash Mostaghimi

Abstract readReview
In one paragraph

Review in Dermatology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samantha GregoireBrigham and Women's Department of Dermatology, 221 Longwood Avenue, Boston, MA, 02115, USA.
Basil McIntoshBrigham and Women's Department of Dermatology, 221 Longwood Avenue, Boston, MA, 02115, USA.
Katherine SanchezBrigham and Women's Department of Dermatology, 221 Longwood Avenue, Boston, MA, 02115, USA.
Ursula BibaBrigham and Women's Department of Dermatology, 221 Longwood Avenue, Boston, MA, 02115, USA.
Arash MostaghimiBrigham and Women's Department of Dermatology, 221 Longwood Avenue, Boston, MA, 02115, USA. amostaghimi@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-6084-5617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata (AA) is an autoimmune condition of non-scarring hair loss that affects 2% of the population worldwide. Topical and intralesional (IL) corticosteroids are the two most commonly used treatments for AA. These locally acting glucocorticoid derivatives are thought to treat AA by reducing the CD8+ T-cell-mediated immune attack on hair follicles. Topical corticosteroids are safe and well tolerated with moderate efficacy in mild AA, but recurrence is common after treatment cessation. They are recommended for children and adults with mild AA who cannot tolerate IL injections. IL steroids are more effective than topical steroids given their ability to penetrate the dermis, where the hair follicle resides. Success rates are higher than topical steroids in mild-to-moderate AA. IL steroids are safe and well tolerated; however, treatment is limited by pain during the procedure. Further research is needed on ideal treatment regimens, long-term safety, preferred candidates, and the role of combination therapy to further elucidate the role of local corticosteroids for AA in clinical practice.

Indexed as

AlopeciaAlopecia areataCorticosteroidsHair lossIntralesional corticosteroidsSteroidsTopical corticosteroids

Identifiers

PMID40323545
PMCPMC12126370

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.