ArticleJapanese journal of radiology2025
Heart volume on health checkup CT scans inversely correlates with pulse rate: data-driven analysis using deep-learning segmentation.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aims to elucidate correlation between heart volume on computed tomography (CT) and various health checkup examination data in the general population. Furthermore, this study aims to examine the utility of a deep-learning segmentation tool in the data-driven analysis of CT big data. MATERIALS AND
methodsHealth checkup examination data and CT images acquired in 2013 and 2018 were retrospectively analyzed. We first quantified heart volume using a public deep-learning model, TotalSegmentator. The accuracy of segmentation was evaluated using Dice score on 30 randomly chosen images and annotation by a radiologist. Then, Spearman's partial correlation was calculated for 58 numerical items, and the analysis of covariance was performed for 13 categorical items, adjusting for the effect of gender, medication, height, weight, abdominal circumference, and age. The variables found to be significant proceeded to longitudinal analysis.
resultsIn the dataset, 7993 records were eligible for cross-sectional analysis and 1306 individuals were eligible for longitudinal analysis. Pulse rate was most strongly inversely correlated with the heart volume (Spearman's correlation coefficients ranging from - 0.29 to - 0.33). A 10 bpm increase in pulse rate was correlated with roughly a 0.5 percentage point decrease in the cardiothoracic ratio. Hemoglobin, hematocrit, total protein, albumin, and cholinesterase also showed weak inverse correlation. Five-year longitudinal analysis corroborated these findings.
conclusionsWe found that pulse rate was the strongest covariate of the heart volume on CT, rather than other cardiovascular-related variables such as blood pressure. The study also demonstrated the feasibility and utility of the artificial intelligence-assisted data-driven research on CT big data.
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