Evidence map›Paper›PMID 40323492›Full record

ArticleDigestive diseases and sciences2025

Impact of Interstitial Cells of Cajal Density and Other Factors on Clinical Outcomes Following G-POEM in Gastroparesis Patients.

Maryam Mubashir, Daniyal Raza, Michelle Neice, Sofia Novacic, Megan Maloz, Rawia Aburumman, Brittany Pass, Natalie Roppolo, Ross Dies, Kshitij Arora and 5 more

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maryam Mubashir *Division of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Daniyal Raza *Division of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Michelle NeiceDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Sofia NovacicDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Megan MalozDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Rawia AburummanDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Brittany PassDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Natalie RoppoloDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Ross DiesDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA.
Kshitij AroraDepartment of Pathology, LSU Health Shreveport, Shreveport, LA, 71106, USA.
James TraylorDepartment of Pathology, LSU Health Shreveport, Shreveport, LA, 71106, USA.
Hidehiro TakeiDepartment of Pathology, LSU Health Shreveport, Shreveport, LA, 71106, USA.
Md Ismail HossainDepartment of Biostatistics and Computational Biology, LSU Health Shreveport, Shreveport, LA, 71106, USA.
Mohammad Alfrad Nobel BhuiyanDepartment of Biostatistics and Computational Biology, LSU Health Shreveport, Shreveport, LA, 71106, USA.
Qiang CaiDivision of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Suite 6-305, Shreveport, LA, 71106, USA. qiang.cai@lsuhs.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastroparesis remains an elusive disorder with debilitating symptoms. There has been some progress in treatment options, such as gastric per oral endoscopic pyloromyotomy (G-POEM). It is unknown whether the number of gastric interstitial cells of Cajal (ICC) is related to the outcome of G-POEM.

methodsAll patients who underwent G-POEM and had gastric muscle biopsy at G-POEM were enrolled. A direct biopsy of the exposed antral smooth muscles was performed during G-POEM to quantify the ICC. The relationship between the outcome of G-POEM and the number of ICC was analyzed.

resultsEighty-four patients were included in this study. The average age was 48.5 years; 77.6% were females, 47.6% of the patients had diabetic gastroparesis, 16.7% had post-surgical gastroparesis, and 35.7% had idiopathic gastroparesis. All the patients had failed other therapy. 82.9% of the patients had no intra or immediate postoperative complications, and the average procedure time was 29 min. 70% of the patients were discharged the same day. The average hospital stay for the rest was 2.6 days. The average time to follow-up was 5 months. 100% of patients had technical success, and 57.4% of patients had clinical success. The average number of ICC/4 mm

conclusionThe association between the number of ICC and the clinical outcomes of G-POEM is not observed in this study. To our knowledge, this is the first such report. Further research on the pathogenesis of gastroparesis is needed.

Indexed as

GastroparesisInterstitial Cells of CajalPyloromyotomyAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeGastroparesisG-POEMICC

Identifiers

PMID40323492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.