ArticleAnalytical and bioanalytical chemistry2025
Dispersive solid-phase extraction as sample pretreatment for determination of chemotherapeutic agents revumenib and venetoclax by HPLC-DAD.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The first nanotechnology-based innovative analytical strategy by means of dispersive solid-phase extraction (DSPE) as a necessary sample treatment approach for the simultaneous determination of revumenib and venetoclax in complex biological matrices such as human blood serum prior to high-performance liquid chromatography hyphenated to diode-array detector (HPLC-DAD) is reported. Several carbon nanotubes were rigorously evaluated as DSPE sorbents to obtain an adequate extraction and preconcentration of these chemotherapeutic agents. The best findings were 8 mg of pristine multi-walled carbon nanotubes (MWCNTs) in borate buffer (pH 10; 10 mM). Under optimized chromatographic conditions, the detection, identification, and determination of both anticancer agents and trazodone (internal standard) were done in less than 8 min of analysis. The HPLC-DAD separation was carried out in a C18 reversed-phase column with a mobile phase including ammonium acetate (pH 7; 10 mM) and methanol throughout a gradient elution mode with a sample flow rate of 0.9 mL min
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