Evidence map›Paper›PMID 40323374›Full record

ArticleAntimicrobial agents and chemotherapy2025

Impact of the double deletion ΔG242-T243 in KPC-2 in the effectiveness of ceftazidime-avibactam and imipenem-relebactam.

Florencia Brunetti, Gabriel Gutkind, Lin Gao, Shozeb Haider, Robert A Bonomo, Pablo Power

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Florencia BrunettiUniversidad de Buenos Aires, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
Gabriel GutkindUniversidad de Buenos Aires, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.ORCID 0000-0003-1999-9785
Lin GaoUCL School of Pharmacy, London, United Kingdom.
Shozeb HaiderUCL School of Pharmacy, London, United Kingdom.ORCID 0000-0003-2650-2925
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X
Pablo PowerUniversidad de Buenos Aires, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.ORCID 0000-0002-7051-9954

Funding

Characterizing novel Beta-lactamases from metagenomic samples: insights into the evolution of antimicrobial resistance from the environment towards human-associated pathogensR01AI160371 · NIAID · UBATEC S.A. · PI Pablo Power · 2022 to 2026
$630k
Agencia Nacional de Promoción Científica y Tecnológica PICT 2021-I-A-00771Consejo Nacional de Investigaciones Científicas y Técnicas 11220200100191CONational Institute of Allergy and Infectious Diseases 1R01AI160371-01A1NIAID NIH HHS R01 AI160371
6 · The paper itself

Abstract

Combinations of β-lactam-diazabicyclooctane inhibitors (DBOs) like ceftazidime-avibactam (CZA) and imipenem-relebactam (IMR) have shown efficacy in treating KPC-2-producing

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeImipenemKlebsiella pneumoniaebeta-Lactamase InhibitorsDrug CombinationsMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-lactamase KPC-2, Klebsiella pneumoniaebeta-LactamasesCeftazidimeDrug CombinationsImipenemrelebactamavibactamCZADBOKlebsiella pneumoniaeKPC-14relebactam

Identifiers

PMID40323374
PMCPMC12135508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.