Evidence map›Paper›PMID 40323354›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Increased expression of proinflammatory cytokines in the cerebrospinal fluid of patients with a history of electrical status epilepticus in sleep.

Xing-Guang Ye, Shi-Wei Dong, Ben-Ze Wu, Zhi-Gang Liu

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Xing-Guang Ye *Department of Pediatrics, Foshan Women and Children Hospital, Foshan, 528000, Guangdong, China.ORCID http://orcid.org/0000-0003-3091-2417
Shi-Wei Dong *Department of Pediatrics, Foshan Women and Children Hospital, Foshan, 528000, Guangdong, China.ORCID http://orcid.org/0009-0000-2713-9203
Ben-Ze Wu *Department of Pediatrics, Foshan Women and Children Hospital, Foshan, 528000, Guangdong, China.ORCID http://orcid.org/0009-0004-4376-3910
Zhi-Gang LiuDepartment of Pediatrics, Foshan Women and Children Hospital, Foshan, 528000, Guangdong, China. zhigangliu88@163.com.ORCID http://orcid.org/0000-0003-0614-1894

Funding

Foshan Science and Technology Bureau Foshan Science and Technology Bureau
6 · The paper itself

Abstract

objectiveThis study was to investigate the cytokine expression profiles in the cerebrospinal fluid (CSF) of Self-limited epilepsy with centrotemporal spikes (SeLECTS) patients with electrical status epilepticus during sleep (ESES) and compare these to other neurological diseases to identify the cytokines that correlate with ESES.

methodsSeven SeLECTS patients with ESES and nine non-ESES controls were included in this study. CSF was centrifuged within one hour and stored at -80 °C; subsequently, High mobility group box 1 (HMGB1), Caspase-1, interleukin (IL)-1β, IL-1α, IL-6, IL-8, IL-10 and tumour necrosis factor-α (TNF-α) were measured with enzyme-linked immunosorbent assay.

resultsCSF levels of IL-1β, TNF-α, IL-1α, and Caspase-1 in ESES group were significantly elevated compared with those non-ESES controls. Moreover, IL-1β CSF levels were positively correlated with Caspase-1 and TNF-α whereas it moderately correlated with IL-1α.

conclusionsThe present study indicates a close relationship between neuroinflammation and ESES pathogenesis in patients with SeLECTS.

Indexed as

CytokinesSleepStatus EpilepticusAdolescentAdultChildFemaleHumansMaleYoung AdultCytokinesCerebrospinal fluidElectrical status epilepticus during sleepInflammatory cytokinesSelf-limited epilepsy with centrotemporal spikes

Identifiers

PMID40323354

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.