Evidence map›Paper›PMID 40323336›Full record

Observational studyAntimicrobial agents and chemotherapy2025

Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy.

Katharina M Götz, Sascha Kreuer, Anke-Katrin Volz, Suzanne L Parker, Jason A Roberts, George Dimopoulos, Thomas Dimski, Detlef Kindgen-Milles, Lisa K V Beuche, Jan T Kielstein and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katharina M GötzSaarmetrics GmbH, Saarland University, Saarbrücken, Germany.ORCID 0009-0005-8963-4329
Sascha KreuerSaarmetrics GmbH, Saarland University, Saarbrücken, Germany.
Anke-Katrin VolzSaarmetrics GmbH, Saarland University, Saarbrücken, Germany.
Suzanne L ParkerUniversity of Queensland Centre for Clinical Research, Faculty of Medicine,The University of Queensland, Brisbane, Queensland, Australia.
Jason A RobertsUniversity of Queensland Centre for Clinical Research, Faculty of Medicine,The University of Queensland, Brisbane, Queensland, Australia.
George DimopoulosThird Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Thomas DimskiDepartment of Anesthesiology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Detlef Kindgen-MillesDepartment of Anesthesiology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Lisa K V BeucheMedical Clinic V (Nephrology, Rheumatology, Blood Purification), Academic Teaching Hospital Braunschweig, Braunschweig, Germany.
Jan T KielsteinMedical Clinic V (Nephrology, Rheumatology, Blood Purification), Academic Teaching Hospital Braunschweig, Braunschweig, Germany.
Thorsten LehrSaarmetrics GmbH, Saarland University, Saarbrücken, Germany.ORCID 0000-0002-8372-1465

Funding

Australian National Health and Medical Research Council APP2007007, APP2009736, Advancing Queensland Clinical Fellowship
6 · The paper itself

Abstract

We investigated the pharmacokinetics (PK) of intravenous fosfomycin in critically ill patients undergoing different types of kidney replacement therapy (KRT) to identify optimized dosing regimens for patient care. Four prospective, observational studies contributed data of critically ill patients with prolonged-intermittent KRT (PIKRT,

Indexed as

Anti-Bacterial AgentsFosfomycinRenal Replacement TherapyAdministration, IntravenousAdultAgedArea Under CurveCritical IllnessFemaleGlomerular Filtration RateHumansMaleMicrobial Sensitivity TestsMiddle AgedMonte Carlo MethodProspective StudiesAnti-Bacterial AgentsFosfomycincritically illdose optimizationfosfomycinkidney replacement therapypopulation pharmacokinetics

Identifiers

PMID40323336
PMCPMC12135532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.