Evidence map›Paper›PMID 40323280›Full record

ArticleAging2025

Dylan Ellis, Kengo Watanabe, Tomasz Wilmanski, Michael S Lustgarten, Andres V Ardisson Korat, Gwênlyn Glusman, Jennifer Hadlock, Oliver Fiehn, Paola Sebastiani, Nathan D Price and 9 more

Abstract read
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Transcriptome Sequencing and Identification ofAnimals : an open access journal from MDPI · 2026
    Article
  3. Review
  4. A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

  • Update of
    2024
5 · Who and what money

Authors and funding

19 authors.

Dylan EllisInstitute for Systems Biology, Seattle, WA 98109, USA.
Kengo WatanabeInstitute for Systems Biology, Seattle, WA 98109, USA.
Tomasz WilmanskiInstitute for Systems Biology, Seattle, WA 98109, USA.
Michael S LustgartenMetabolism and Basic Biology of Aging, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Andres V Ardisson KoratJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Gwênlyn GlusmanInstitute for Systems Biology, Seattle, WA 98109, USA.
Jennifer HadlockInstitute for Systems Biology, Seattle, WA 98109, USA.
Oliver FiehnWest Coast Metabolomics Center, University of California, Davis, CA 95616, USA.
Paola SebastianiInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA.
Nathan D PriceThorne HealthTech, New York, NY 10019, USA.
Leroy HoodInstitute for Systems Biology, Seattle, WA 98109, USA.
Andrew T MagisInstitute for Systems Biology, Seattle, WA 98109, USA.
Simon J EvansPhenome Health, Seattle, WA 98109, USA.
Lance PfliegerPhenome Health, Seattle, WA 98109, USA.
Jennifer C LovejoyInstitute for Systems Biology, Seattle, WA 98109, USA.
Sean M GibbonsInstitute for Systems Biology, Seattle, WA 98109, USA.
Cory C FunkInstitute for Systems Biology, Seattle, WA 98109, USA.
Priyanka BaloniInstitute for Systems Biology, Seattle, WA 98109, USA.
Noa RappaportInstitute for Systems Biology, Seattle, WA 98109, USA.

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
CTSA K12 Program at Tufts UniversityK12TR004384 · NCATS · TUFTS UNIVERSITY BOSTON · PI Karen Freund, Lesley Ann Inker · 2023 to 2026
$6.1M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
Protein Signatures of APOE2 and Cognitive AgingR01AG061844 · NIA · TUFTS MEDICAL CENTER · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2018 to 2022
$3.1M
Medical Research CouncilNCATS NIH HHS K12 TR004384NIA NIH HHS R01 AG061844NIA NIH HHS U19 AG023122NIA NIH HHS UH3 AG064706Wellcome Trust
6 · The paper itself

Abstract

Apolipoprotein E (

Indexed as

AgingApolipoproteins EEnergy MetabolismAgedAged, 80 and overAllelesFemaleGenotypeHumansInsulin ResistanceLongevityMaleMiddle AgedApoE protein, humanApolipoproteins EAlzheimer’s disease (AD)apolipoprotein E (APOE)biological ageinsulin resistancemetabolism

Identifiers

PMID40323280
PMCPMC12151507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.