ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Reinforced Granular Hydrogels Scaffolds with Tunable Physicochemical Properties for Advanced Skin Tissue Engineering.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Spontaneous Non-Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Brick by Brick the Wall Is Being Built: Particle-Based Scaffolds for Regenerative Medicine.Polymers · 2025Review
- Reinforced Granular Hydrogels Scaffolds with Tunable Physicochemical Properties for Advanced Skin Tissue Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Engineering bioscaffolds with tailored architectures and optimized physicochemical properties remains a crucial yet challenging goal in tissue engineering and regenerative medicine. In this study, the design of reinforced concrete-inspired annealed granular hydrogel (GH) scaffolds that meet the essential yet often conflicting requirements for bioscaffolds: providing adequate mechanical strength while facilitating cell infiltration, nutrient exchange, and the formation of complex cellular networks. GH building blocks are synthesized using a binary macromonomer system of hyperbranched polyethylene glycol and thiolated gelatin within microfluidic droplets, benefiting from the molecular interface assembly and templating effects of the microdroplets, which possess highly reactive vinyl functional groups, thereby endowing the annealed GH scaffolds with highly customizable properties. The versatility of this platform is demonstrated by the creation of full-thickness engineered skin tissues that support keratinocyte attachment and differentiation; the formation of a mature epidermis, complete with a developed stratum corneum, and the expression of key markers, such as keratin 10 and keratin 14, while minimizing contraction over long-term culturing, a common limitation of traditional collagen-based scaffolds. Owing to their biocompatibility, tunable mechanical properties, ease of surface functionalization, and compatibility with bioprinting, these scaffolds have significant potential for applications in tissue engineering, drug delivery, and bioprinting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.