Evidence map›Paper›PMID 40323223›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Model-Guided Rational Construction of Escherichia coli Synthetic Consortia for Enhanced 2-Methylbutyric Acid Production.

Yu Liu, Boyuan Xue, Shaojie Wang, Haijia Su

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Systematically Engineering for Efficient Production of 3-Methyl-1-Butanol in Escherichia coli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu LiuState Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Laboratory of Green Chemicals Biomanufacturing, Beijing Synthetic Bio-manufacturing Technology Innovation Center, Beijing, 102209, P. R. China.
Boyuan XueState Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Laboratory of Green Chemicals Biomanufacturing, Beijing Synthetic Bio-manufacturing Technology Innovation Center, Beijing, 102209, P. R. China.
Shaojie WangState Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Laboratory of Green Chemicals Biomanufacturing, Beijing Synthetic Bio-manufacturing Technology Innovation Center, Beijing, 102209, P. R. China.ORCID https://orcid.org/0000-0003-2706-3581
Haijia SuState Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Laboratory of Green Chemicals Biomanufacturing, Beijing Synthetic Bio-manufacturing Technology Innovation Center, Beijing, 102209, P. R. China.ORCID https://orcid.org/0000-0002-4266-7212

Funding

Beijing Natural Science Foundation 2252017Fundamental Research Funds for the Central Universities JD2537Jiangxi Province Double Thousand Plan High-level Innovation Team Project S2020CXTD0240National Key R&D Program of China 2021YFC2100700National Natural Science Foundation of China 21838001National Natural Science Foundation of China 31961133018
6 · The paper itself

Abstract

Synthetic consortia represent an innovative and effective platform that can significantly alleviate the metabolic burden on host organisms and enable flexible regulation of biosynthetic pathways. However, designing a stable synthetic consortium remains a significant challenge. In this study, a novel citramalate -derived pathway is first developed for 2-methylbutyric acid (2MBA) biosynthesis in an E. coli mono-culture system, achieving a titer of 678.78 ± 49.04 mg L

Indexed as

Escherichia coliMetabolic EngineeringMicrobial ConsortiaBiosynthetic Pathwaysco‐culturemetabolic engineeringmetabolic network modelrational constructionsynthetic consortia

Identifiers

PMID40323223
PMCPMC12165103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.