SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025
Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.
Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOsteoradionecrosis (ORN) is a recognized complication of radiotherapy. However, calvarial ORN (ORNC) following treatment for cutaneous malignancies is poorly understood. Shedding light on the limited evidence to date, this study aims to summarize existing evidence and highlight the research gaps. DATA SOURCES: PubMed and Embase. REVIEW
methodsA systematic search of PubMed and Embase was conducted up to May 2024, using relevant keywords to identify papers on ORNC. Data on the definition, incidence, risk factors, radiotherapy parameters, diagnostic methods, and management strategies were collected.
resultsTwenty articles reporting on 42 ORNC patients were identified, revealing relatively poor data quality. There remains no consensus on a definition of ORNC. Patient- and disease-related risk factors have been inconsistently documented. No conclusion could be reached regarding thresholds for radiation dose delivery, as only seven studies reported the total radiation dose, with a mean of 58.9 Gy. Twenty-five (60%) cases managed with wound care and antibiotics demonstrated a spectrum of success rates, while 90% of surgically managed ORNC wounds healed at various follow-up points, ranging from 6 weeks to 9 years.
conclusionThis study proposes an ORNC-specific definition and reporting standard through comparison with mandibular ORN. This will help generate valuable data, guiding the development of an ORNC-specific treatment protocol and clinical decision-making in managing this debilitating side effect of radiotherapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.