ArticleThe Laryngoscope2025
Partial Decellularization Retains Cartilage Immune Privilege in Tissue Engineered Tracheal Grafts.
Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biointegration of a partially decellularized tracheal scaffold in a porcine model - preliminary results.Scientific reports · 2026Article
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7 authors.
Funding
Abstract
objectivesTracheal allografts have been used to reconstruct the human airway. However, the need for immunosuppression could ultimately limit their clinical translation. Partial decellularization (PD) has the potential to eliminate allograft immunogenicity while preserving donor cartilage. This study measures the effect of immunogenicity on tracheal allografts and PD on cartilage immunogenicity in partially decellularized tracheal grafts (PDTG).
methodsNative and partial-decellularized trachea from C57BL/6 (control) and BALB/c (allograft, ATG) mice were transplanted orthotopically in C57BL/6 hosts (N = 3-10/group). At 10 days, 1 month, and 3 months, cartilage degradation, characterized as loss of chondrocytes and extracellular matrix (ECM) was assessed histologically. Acute and chronic rejection were measured with immunofluorescence CD4 and CD8 T lymphocyte infiltration.
resultsOf 41 animals, 35 survived to endpoint and all grafts remained patent. Allografts exhibited cartilage degradation (loss of glycosaminoglycans, collagen, and chondrocytes) in 95.8% of animals versus 0% of animals that received syngeneic tracheal grafts (STG, control). In contrast to allografts, cartilage degradation was observed in 3.7% and 8.7% of partially decellularized grafts derived from syngeneic and allograft donors, respectively. ATG demonstrated more cartilage degradation and T-lymphocyte infiltration at each time point compared to STG and PDTG. T-cell infiltration peaked at 1 month. All grafts demonstrated more calcification (higher radiodensity) than the host (p < 0.05) in vivo.
conclusionIn our mouse microsurgical model, we observed that in the absence of immunosuppression, tracheal allografts undergo cartilage degradation with associated T-cell infiltration. This phenomenon is not observed in grafts that underwent partial decellularization. LEVEL OF EVIDENCE: N/A.
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