ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- NSD2 Coordinates the Neurogenic-to-Gliogenic Transition via H3K36me2-Dependent Activation of the EGFR-ERK Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endothelial-specific Ezh2 deficiency exacerbates blood-brain barrier dysfunction and neuroinflammation in sepsis-associated encephalopathy.Journal of neuroinflammation · 2026Article
- Article
- Faf2 is required for neural differentiation in embryonic neural progenitor cells.Frontiers in cell and developmental biology · 2026Article
- Sex-dimorphic reprogramming of fetal mouse brain development by maternal estradiol excess.Biology of sex differences · 2025Article
- Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The development of the brain involves the proliferation of neural stem cells (NSCs) and the differentiation of neurogenic cells, including neurons, astrocytes, and oligodendrocytes. The growth and development of other cells in the brain, including microglia and blood vessels, are also crucial for maintaining normal brain function. In the first part, the intrinsic regulatory mechanisms of NSCs during neurogenesis are primarily delved into. This focused on the effects of epigenetic modifications on the proliferation and differentiation of NSCs. Additionally, the phenomenon where their own proliferative behavior leads to the activation of immune-related genes are discussed. Furthermore, the impact of maternal immune activation on neurogenesis are explored. Finally, the reasons underlying differences in brain development between humans and mice are examined. In the second part, the development and origin of microglia, their heterogeneity during the developmental process, and the impact of microglia on the development of surrounding cells are delved into. In the third part, the relationship between the cerebrovascular system and brain development are explored. This includes the communication and interaction between blood vessels and NSCs, as well as the effects of cytokines secreted by blood vessels on synapses and the genesis of glial cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.