Evidence map›Paper›PMID 40323161›Full record

ArticleBiochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Using ChatGPT as a tool for training nonprogrammers to generate genomic sequence analysis code.

Haley A Delcher, Enas S Alsatari, Adeyeye I Haastrup, Sayema Naaz, Lydia A Hayes-Guastella, Autumn M McDaniel, Olivia G Clark, Devin M Katerski, Francois O Prinsloo, Olivia R Roberts and 7 more

Abstract read
In one paragraph

Article in Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Using ChatGPT as a tool for training nonprogrammers to generate genomic sequence analysis code.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Haley A DelcherDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Enas S AlsatariDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Adeyeye I HaastrupDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Sayema NaazDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Lydia A Hayes-GuastellaStokes School of Marine and Environmental Sciences, University of South Alabama, Mobile, Alabama, USA.ORCID 0000-0002-4451-1414
Autumn M McDanielDepartment of Biomedical Sciences, University of South Alabama, Mobile, Alabama, USA.
Olivia G ClarkDepartment of Biology, University of South Alabama, Mobile, Alabama, USA.
Devin M KaterskiDepartment of Biology, University of South Alabama, Mobile, Alabama, USA.
Francois O PrinslooDepartment of Biology, University of South Alabama, Mobile, Alabama, USA.
Olivia R RobertsDepartment of Biology, University of South Alabama, Mobile, Alabama, USA.
Meredith A ShaddixDepartment of Biomedical Sciences, University of South Alabama, Mobile, Alabama, USA.
Bridgette N SullivanDepartment of Biology, University of South Alabama, Mobile, Alabama, USA.
Isabella M SwanDepartment of Biology, University of South Alabama, Mobile, Alabama, USA.
Emily M HartsellDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Jeffrey D DeMeisDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Sunita S PaudelDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.
Glen M BorchertDepartment of Pharmacology, University of South Alabama, Mobile, Alabama, USA.ORCID 0000-0002-6182-7154

Funding

Division of Integrative Organismal Systems NSF2243532 (GMB)Division of Molecular and Cellular Biosciences NSF2219900 (GMB)
6 · The paper itself

Abstract

Today, due to the size of many genomes and the increasingly large sizes of sequencing files, independently analyzing sequencing data is largely impossible for a biologist with little to no programming expertise. As such, biologists are typically faced with the dilemma of either having to spend a significant amount of time and effort to learn how to program themselves or having to identify (and rely on) an available computer scientist to analyze large sequence data sets. That said, the advent of AI-powered programs like ChatGPT may offer a means of circumventing the disconnect between biologists and their analysis of genomic data critically important to their field. The work detailed herein demonstrates how implementing ChatGPT into an existing Course-based Undergraduate Research Experience curriculum can provide a means for equipping biology students with no programming expertise the power to generate their own programs and allow those students to carry out a publishable, comprehensive analysis of real-world Next Generation Sequencing (NGS) datasets. Relying solely on the students' biology background as a prompt for directing ChatGPT to generate Python codes, we found students could readily generate programs able to deal with and analyze NGS datasets greater than 10 gigabytes. In summary, we believe that integrating ChatGPT into education can help bridge a critical gap between biology and computer science and may prove similarly beneficial in other disciplines. Additionally, ChatGPT can provide biological researchers with powerful new tools capable of mediating NGS dataset analysis to help accelerate major new advances in the field.

Indexed as

Computational BiologyGenomicsSequence Analysis, DNASoftwareCurriculumGenerative Artificial IntelligenceHigh-Throughput Nucleotide SequencingHumansStudentsactive learningcomputational biologycomputers in research and teachingcurriculum design development and implementationgenomics proteomics bioinformaticsintegration of research into undergraduate teachingoriginal models for teaching and learning

Identifiers

PMID40323161
PMCPMC12290243

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.