Evidence map›Paper›PMID 40323140›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

Tumor Hypoxia and CD8

Joshua D Smith, Elizabeth Gensterblum-Miller, David W A Forner, Pratyusha Yalamanchi, Marisa R Buchakjian, Steven B Chinn, Andrew G Shuman, Keith A Casper, Kelly M Malloy, Chaz L Stucken and 9 more

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In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Joshua D SmithDepartment of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Elizabeth Gensterblum-MillerDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
David W A FornerDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Pratyusha YalamanchiDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Marisa R BuchakjianDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Steven B ChinnDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Andrew G ShumanDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Keith A CasperDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Kelly M MalloyDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Chaz L StuckenDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Scott A McleanDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Michelle L MierzwaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Jennifer ShahDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Paul L SwiecickiRogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
Francis P WordenRogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
Mark E P PrinceDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Matthew E SpectorDepartment of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
J Chad BrennerDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Molly E Heft NealDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Advanced Research Training in OtolaryngologyT32DC005356 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORFAS, GABRIEL · 2002 to 2021
$3.5M
NIDCD NIH HHS T32 DC005356
6 · The paper itself

Abstract

objectiveWe assessed correlations between tumor carbonic anhydrase IX (CAIX) staining, as a marker of tumor hypoxia, and CD8 STUDY

designRetrospective cohort study.

settingTertiary care hospital.

methodsPatients with stage III to IV laryngeal squamous cell carcinoma treated under a bioselection paradigm were included. Immunohistochemistry for CD8

resultsOur cohort included 92 patients (n = 68 [73.9%] supraglottic). No difference in CAIX staining was seen by tumor subsite, stage, and response to induction chemotherapy (all P > .05). Thirteen (14.1%) tumors were CAIX-positive and showed significantly lower CD8

conclusionCAIX staining correlates with reduced CD8

Indexed as

Carcinoma, Squamous CellCD8-Positive T-LymphocytesLaryngeal NeoplasmsLymphocytes, Tumor-InfiltratingTumor HypoxiaAdultAgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorCarbonic Anhydrase IXFemaleHumansImmunohistochemistryMaleMiddle AgedAntigens, NeoplasmBiomarkers, TumorCA9 protein, humanCarbonic Anhydrase IXcarbonic anhydrasehypoxialarynxsquamous cell carcinomaTIL

Identifiers

PMID40323140
PMCPMC12354137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.