Evidence map›Paper›PMID 40323137›Full record

ArticleEquine veterinary journal2026

Effect of high-speed exercise on subchondral bone in the metacarpo-/metatarsophalangeal joints of 2-year-old Thoroughbred racehorses in their first year of training.

Sarah A Ciamillo, Kathryn W Bills, Taryn M Gassert, Dean W Richardson, Kara A Brown, Darko Stefanovski, Kyla F Ortved

Abstract read
In one paragraph

Article in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah A CiamilloDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Kathryn W BillsDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0857-9363
Taryn M GassertSports Medicine Associates of Chester County, Cochranville, Pennsylvania, USA.
Dean W RichardsonDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Kara A BrownDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Darko StefanovskiDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4654-0569
Kyla F OrtvedDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0398-2444

Funding

Grayson-Jockey Club Research Foundation
6 · The paper itself

Abstract

backgroundStress-induced bone injury can lead to catastrophic injuries in Thoroughbred racehorses. Accumulation of high-speed exercise can increase the risk of subchondral bone injury.

objectivesTo investigate the effect of high-speed exercise on the subchondral bone of the metacarpo-metatarsophalangeal (MCP/MTP) joints using standing cone-beam computed tomography (CBCT) in young racing Thoroughbreds. STUDY

designObservational cohort study.

methodsForty-one 2-year-old Thoroughbred racehorses during their first year of training were evaluated at 0, 6 and 12 months. Horses were evaluated for lameness and effusion of the MCP/MTP joints, and then standing CBCT was performed of the MCP/MTP joints. Subchondral bone hyperdensity (sclerosis) was measured (mm) at defined locations in the distal aspect of the third metacarpal (MC3)/metatarsal (MT3) bone and proximal phalanx (P1). CBCT scans were evaluated for subchondral bone hypodensity (pathology) in MC3/MT3, P1 and proximal sesamoid bones. Racing and training records were obtained from a national online database and trainers.

resultsSubchondral bone sclerosis (coefficient = 0.45; p < 0.003; 95% confidence interval [CI] 0.16-0.74) and pathology (IRR = 1.01; p < 0.001; 95% CI 1.00-1.01) increased significantly with the number of high-speed furlongs accumulated. Lameness was not associated with sclerosis or pathology; however, joint effusion was associated with both sclerosis (IRR = 1.01; p = 0.02; 95% CI 1.00-1.02) and pathology lesion (IRR = 1.14; p < 0.01; 95% CI 1.04-1.25). MAIN LIMITATIONS: Limitations include attrition of horses over time and lack of control over training and husbandry.

conclusionsAn increase in high-speed work was associated with both an increase in subchondral bone sclerosis and pathology.

Indexed as

Physical Conditioning, AnimalAnimalsCohort StudiesFemaleForelimbHorsesMalefurlonghigh‐speed exercisehorseinjury preventionsubchondral bone pathology

Identifiers

PMID40323137
PMCPMC12699115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.