Evidence map›Paper›PMID 40323101›Full record

ArticlemBio2025

The AusAB non-ribosomal peptide synthetase of

Adriana Moldovan, Markus Krischke, Claudia Huber, Clara Hans, Martin J Müller, Wolfgang Eisenreich, Thomas Rudel, Martin J Fraunholz

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adriana MoldovanBiocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-1369-5078
Markus KrischkeBiocenter, Chair of Pharmaceutical Biology, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-2738-0053
Claudia HuberBavarian NMR Center-Structural Membrane Biochemistry, Department of Bioscience, School of Natural Sciences, Technical University of Munich, Munich, Germany.ORCID 0000-0002-1204-8162
Clara HansBiocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany.
Martin J MüllerBiocenter, Chair of Pharmaceutical Biology, University of Würzburg, Würzburg, Germany.
Wolfgang EisenreichBavarian NMR Center-Structural Membrane Biochemistry, Department of Bioscience, School of Natural Sciences, Technical University of Munich, Munich, Germany.ORCID 0000-0002-9832-8279
Thomas RudelBiocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-4740-6991
Martin J FraunholzBiocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-4581-6244

Funding

Deutsche Forschungsgemeinschaft EI 384/16-1Deutsche Forschungsgemeinschaft RU 631/17-1Deutscher Akademischer Austauschdienst STIBETGraduate School of Life Sciences, Julius-Maximilians-Universität Würzburg German Excellence Initiative
6 · The paper itself

Abstract

Non-ribosomal peptide synthetases (NRPSs) are modular multidomain enzymes responsible for the biosynthesis of various secondary metabolites in an mRNA template-independent manner. They are predominantly present in bacteria and fungi, where they synthesize a variety of products, including antibiotics, siderophores, toxins, and signaling molecules. The human pathogen IMPORTANCE: Peptide and protein synthesis are fundamental processes in nature which are largely mediated by the ribosomal machinery. An alternative pathway for peptide synthesis is non-ribosomal mRNA template-independent synthesis, performed by so-called NRPSs. NRPSs are multi-enzyme complexes which serve the simultaneous role of template and biosynthetic machinery. They are mostly found in bacteria and fungi and are responsible for the biosynthesis of many pharmacologically significant products, including antibiotics, anticancer compounds, or immunosuppressants. The human pathogen

Indexed as

Bacterial ProteinsCulture MediaPeptide SynthasesStaphylococcus aureusValineHumansPhenylalanineBacterial ProteinsCulture Medianon-ribosomal peptide synthasePeptide SynthasesPhenylalanineValineaureusiminesnon-ribosomal peptide synthetasesphevalinStaphylococcus aureustyrvalin

Identifiers

PMID40323101
PMCPMC12153313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.