Evidence map›Paper›PMID 40322922›Full record

ArticleJournal of animal science2025

Dietary resveratrol improves semen quality by promoting mitochondrial function-related genes expression in aging boars.

Jing Lv, Wentao Zhang, Ruizhi Hu, Xizi Yang, Jiatai Gong, Siqi Ma, Hongkun Xiang, Xupeng Yuan, Hongfu Zhang, Xi He and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jing LvCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Wentao ZhangCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Ruizhi HuCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Xizi YangCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Jiatai GongCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Siqi MaCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Hongkun XiangCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Xupeng YuanCollege of Animal Science and Technology, Hunan Biological and Electromechanical Polytechnic, Changsha, China.
Hongfu ZhangState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Xi HeCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Jianhua HeCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.ORCID 0000-0002-9289-4405
Rejun FangCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.
Shusong WuCollege of Animal Science and Technology, Yuelushan Laboratory, Hunan Agricultural University, Changsha, China.

Funding

National Key R&D Program of China 2023YFD1301200National Key R&D Program of China 2023YFD1302300National Natural Science Foundation of China U22A20515
6 · The paper itself

Abstract

Boar semen quality is a significant factor affecting reproductive efficiency in modern farms, and resveratrol (RES) has the potential to reduce mouse sperm mortality in our previous studies. Here, we found that dietary supplementation of RES (500 mg/kg) delayed the decline in semen quality by increasing sperm motility and survivability in aging boars (P < 0.01, n = 6) by a 12-wk trial. RES increased the testosterone level and total antioxidant capacity (P < 0.01), while decreasing the cortisol (P < 0.05) and malondialdehyde (MDA, P < 0.01) in serum. Immunofluorescence assay and electron microscope scanning revealed that RES reduced the levels of reactive oxygen species, 8-hydroxy-2'-deoxyguanosine, and MDA (P < 0.01) to alleviate oxidative damage in semen. Analysis of mitochondrial function-related genes indicated that RES improved mitochondrial structural integrity and mitochondrial membrane potential (P < 0.01) by increasing the mRNA expression of PGC-1α, TFB1M, and TFB2M (P < 0.01). These results demonstrated that RES can enhance semen quality and antioxidant capacity potentially through improving sperm mitochondrial function in aging boars.

Indexed as

AgingGene Expression RegulationMitochondriaResveratrolSemen AnalysisAnimal FeedAnimalsAntioxidantsDietDietary SupplementsMaleSpermatozoaSwineAntioxidantsResveratrolaging boarantioxidant capacitymitochondrial functionresveratrolsemen quality

Identifiers

PMID40322922
PMCPMC12311920

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.