Evidence map›Paper›PMID 40322916›Full record

ArticleNucleic acids research2025

WashU Epigenome Browser update 2025.

Chanrung Seng, Shane Liu, Wenjin Zhang, Xiaoyu Zhuo, Daofeng Li, Ting Wang

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chanrung SengDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.
Shane LiuDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.
Wenjin ZhangDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.ORCID 0000-0002-5979-0102
Xiaoyu ZhuoDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.
Daofeng LiDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.ORCID 0000-0001-7492-3703
Ting WangDepartment of Genetics, The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States.ORCID 0000-0002-6800-242X

Funding

Center for Multiomic Human Brain Cell AtlasUM1MH130994 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MARIA MARGARITA BEHRENS, Joseph R Ecker · 2022 to 2026
$92.4M
The WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9M
WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating CenterU24HG012070 · NHGRI · WASHINGTON UNIVERSITY · PI Ting Wang, Feng Yue · 2021 to 2026
$9.7M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational CenterU24NS132103 · NINDS · WASHINGTON UNIVERSITY · PI FULTON, LUCINDA, LAWSON, HEATHER A. · 2023 to 2025
$4.5M
DECODING THE IMPACT OF TRANSPOSABLE ELEMENTS ON GENE REGULATIONR01HG007175 · NHGRI · WASHINGTON UNIVERSITY · PI WANG, TING · 2014 to 2021
$2.7M
Connecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4M
The WashU 4DN Network Data Coordination and Integration CenterU01CA200060 · NCI · WASHINGTON UNIVERSITY · PI WANG, TING · 2015 to 2019
$1.9M
NCI NIH HHS U01 CA200060NHGRI NIH HHS R01 HG007175NHGRI NIH HHS R01HG007175NHGRI NIH HHS U01CA200060NHGRI NIH HHS U01 HG009391NHGRI NIH HHS U01HG009391NHGRI NIH HHS U24 HG012070NHGRI NIH HHS U24HG012070NHGRI NIH HHS U41 HG010972NHGRI NIH HHS U41HG010972NHGRI NIH HHS UM1 HG011585NHGRI NIH HHS UM1HG011585NHGRI NIH HHS UM1MH130994NIMH NIH HHS UM1 MH130994NINDS NIH HHS U24 NS132103
6 · The paper itself

Abstract

The WashU Epigenome Browser (https://epigenomegateway.wustl.edu/) is a web-based tool for exploring genomic data and providing visualization, investigation, and analysis of epigenomic datasets. Since its 2018 update, the redesigned user interface and newly developed features have enhanced how investigators interact with both the Browser and the extensive genomic data it hosts. The rapid evolution of the JavaScript ecosystem has presented new challenges and opportunities in maintaining and developing the WashU Epigenome Browser. In this update, we present a completely rewritten codebase. This new codebase minimizes the use of external libraries whenever possible, resulting in a significantly smaller code bundle size after production compilation. The reduced code size improves loading efficiency and boosts the Browser's performance, with improved scripting, graphics rendering, and painting performance. Lowering external dependencies also allows for faster and more straightforward installation. Additionally, the update includes a redesign of the user interface to further enhance user experience and features a new modular design in the codebase that enables the Browser to be exported as stand-alone modules for use in other web applications. Several novel track types for long-read methylation data and single-cell methylation data visualization have been added, and we continue to update and expand the data hubs we host for major consortia. We constructed the first data hub to systematically compare genomic data mapped to different genome assemblies, focusing on comparisons between hg38 and the first human T2T genome, chm13, using our new comparative genomics track function. The WashU Epigenome Browser also serves as a foundation for other genomics platforms, such as the WashU Virus Genome Browser, developed for SARS-COV-2 research, the WashU Comparative Epigenome Browser, and the WashU Repeat Browser.

Indexed as

EpigenomeEpigenomicsSoftwareWeb BrowserCOVID-19Databases, GeneticGenomicsHumansInternetSARS-CoV-2User-Computer Interface

Identifiers

PMID40322916
PMCPMC12230663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.