Evidence map›Paper›PMID 40322860›Full record

Observational studyInternational journal of dermatology2025

Outcomes of a Non-Surgical Combination Therapy for Keloids in Skin of Color Patients: A 10-Year Follow-Up Study.

Marina Patrus Ananias de Souza Brandão, Carolina Fernandes Otoni Vieira, Daniel Brasil Braga Rocha, Márcio Roberto Silva, Jussara Aparecida da Silva, Michael H Gold, Gisele Viana de Oliveira

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marina Patrus Ananias de Souza BrandãoPost Graduation Department, Medical Sciences Faculty of Minas Gerais (FCMMG), Belo Horizonte, Brazil.
Carolina Fernandes Otoni VieiraPost Graduation Department, Medical Sciences Faculty of Minas Gerais (FCMMG), Belo Horizonte, Brazil.
Daniel Brasil Braga RochaPost Graduation Department, Medical Sciences Faculty of Minas Gerais (FCMMG), Belo Horizonte, Brazil.
Márcio Roberto SilvaEMBRAPA Gado de Leite, Juiz de Fora, Brazil.
Jussara Aparecida da SilvaPhysiotherapy Department, GV Dermatology, Belo Horizonte, MG, Brazil.
Michael H GoldGold Skin Care Dermatology, Nashville, Tennessee, USA.
Gisele Viana de OliveiraPost Graduation Department, Medical Sciences Faculty of Minas Gerais (FCMMG), Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-5101-7097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKeloid treatment remains challenging due to high recurrence rates, particularly in patients with higher phototypes. This study aimed to assess the resolution, patient satisfaction, and recurrence rates in 79 keloids treated with a sequential non-surgical protocol combining long-term occlusion with hydrocolloid dressings, monthly injections of triamcinolone and 5-fluorouracil (5-FU), and intense pulsed light therapy. This approach is expected to lower recurrence, improve resolution, and increase patient satisfaction compared to traditional treatments.

methodsThis longitudinal observational study included 79 keloids in 55 patients with Fitzpatrick phototypes III or higher. Data were collected retrospectively from medical records and clinical appointments. Patients were followed for 19-123 months after completing treatment. Outcomes evaluated included keloid resolution, patient satisfaction, and recurrence rates.

resultsThe patients had a mean age of 39 years and underwent treatment for a median of 10 months. Pain was reported in 8.9% of cases, and only one recurrence (1.3%) occurred five years post-treatment. Complete resolution was achieved in 82.3% of keloids, and 94.9% of patients reported maximum satisfaction.

conclusionsThe sequential non-surgical approach evaluated in this study demonstrated low recurrence and high satisfaction rates. Thus, it may represent a promising treatment option for keloid patients with higher phototypes.

Indexed as

FluorouracilGlucocorticoidsIntense Pulsed Light TherapyKeloidTriamcinoloneAdolescentAdultCombined Modality TherapyEthnic and Racial MinoritiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedOcclusive DressingsFluorouracilGlucocorticoidsTriamcinoloneASAP protocolFitzpatrick skin phototypeintense pulsed laser therapykeloidsrecurrenceskin of colortreatment guideline

Identifiers

PMID40322860
PMCPMC12256714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.