Evidence map›Paper›PMID 40322849›Full record

ArticleBiometrics2025

Double robust variance estimation with parametric working models.

Bonnie E Shook-Sa, Paul N Zivich, Chanhwa Lee, Keyi Xue, Rachael K Ross, Jessie K Edwards, Jeffrey S A Stringer, Stephen R Cole

Abstract read
In one paragraph

Article in Biometrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bonnie E Shook-SaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.ORCID 0000-0001-9506-4047
Paul N ZivichDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Chanhwa LeeDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.ORCID 0000-0003-4828-9416
Keyi XueDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Rachael K RossDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York City, NY 10032, United States.
Jessie K EdwardsDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Jeffrey S A StringerDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Stephen R ColeDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.

Funding

Improved analysis of experiments and observational studies in HIVR01AI157758 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephen R Cole, Jessie Edwards · 2020 to 2026
$5.0M
Causal Inference in Infectious Disease Prevention StudiesR01AI085073 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUDGENS, MICHAEL G · 2010 to 2024
$4.5M
Combining sources of information to improve HIV pre-exposure prophylaxisK01AI177102 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Paul Nicholas Zivich · 2023 to 2026
$545k
Generalizing Effects of Infectious Disease Prevention Interventions in the Presence of InterferenceK01AI182506 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHOOK-SA, BONNIE E · 2024 to 2025
$340k
NIAID NIH HHS K01 AI177102NIAID NIH HHS K01 AI182506NIAID NIH HHS R01 AI085073NIAID NIH HHS R01 AI157758NIH HHS R01 AI157758
6 · The paper itself

Abstract

Doubly robust estimators have gained popularity in the field of causal inference due to their ability to provide consistent point estimates when either an outcome or an exposure model is correctly specified. However, for nonrandomized exposures, the influence function based variance estimator frequently used with doubly robust estimators of the average causal effect is only consistent when both working models (ie, outcome and exposure models) are correctly specified. Here, the empirical sandwich variance estimator and the nonparametric bootstrap are demonstrated to be doubly robust variance estimators. That is, they are expected to provide valid estimates of the variance leading to nominal confidence interval coverage when only 1 working model is correctly specified. Simulation studies illustrate the properties of the influence function based, empirical sandwich, and nonparametric bootstrap variance estimators in the setting where parametric working models are assumed. Estimators are applied to data from the Improving Pregnancy Outcomes with Progesterone (IPOP) study to estimate the effect of maternal anemia on birth weight among women with HIV.

Indexed as

BiometryModels, StatisticalAnemiaBirth WeightComputer SimulationData Interpretation, StatisticalFemaleHIV InfectionsHumansPregnancyPregnancy OutcomeProgesteroneProgesteroneaugmented inverse probability weightingcausal inferencedouble robustnessempirical sandwich varianceM-estimation

Identifiers

PMID40322849
PMCPMC12050975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.