Evidence map›Paper›PMID 40322777›Full record

ArticleBrain communications2025

Microglia positron emission tomography and progression in multiple sclerosis: thalamus on fire.

Burcu Zeydan, Nur Neyal, Jiye Son, Christopher G Schwarz, June C Kendall Thomas, Holly A Morrison, Melissa L Bush, Robert I Reid, Scott A Przybelski, Angela J Fought and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Burcu ZeydanDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-2270-9868
Nur NeyalDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0003-2959-4271
Jiye SonDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-1466-8357
June C Kendall ThomasDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Holly A MorrisonCenter for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Melissa L BushCenter for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Robert I ReidDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Scott A PrzybelskiDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Angela J FoughtDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0001-7916-622X
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-8001-2081
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Laura AirasTurku PET Center and Division of Clinical Neurosciences, University of Turku, Turku 20521, Finland.
Orhun H KantarciCenter for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Mayo Clinic Building Interdisciplinary Research Careers in Women’s HealthK12AR084222 · NIAMS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2023 to 2024
$733k
NIAMS NIH HHS K12 AR084222NIA NIH HHS P50 AG016574NIA NIH HHS U01 AG006786
6 · The paper itself

Abstract

Increased innate immune activity promotes neurodegeneration and contributes to progression in multiple sclerosis. This prospective case-control study aims to investigate thalamic microglia density on 18kDa translocator protein PET in patients with multiple sclerosis using a third-generation radioligand,

Indexed as

11C-ER176 positron emission tomographymagnetic resonance imagingmicrogliamultiple sclerosisthalamus

Identifiers

PMID40322777
PMCPMC12046125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.