ArticleNeuropsychiatric disease and treatment2025
Potential Inflammatory Biomarkers and Differential Gut Microbiota in Cognitive Impairment After Ischemic Stroke.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The gut microbiota dysbiosis in ischemic stroke: a systematic review and meta-analysis of microbial diversity and taxonomic alterations.Frontiers in aging neuroscience · 2026Pooled it
- Mechanisms and biomarkers of poststroke cognitive impairment.Neural regeneration research · 2026Article
- Gut microbiota-mediated neuroinflammation following stroke: mechanisms and intervention strategies.Journal of translational medicine · 2026Review
- Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026Review
- The XGBoost Model Versus the Logistic Regression Model Created Based on Serum Markers in Predicting the Risk of Post-Stroke Cognitive Impairment Following Acute Ischemic Stroke.Brain and behavior · 2026Article
- Effects of exercise with probiotics, exercise alone, and probiotics alone on physical, motor, affective, and cognitive functions in stroke patients: a randomised controlled trial.BMC sports science, medicine & rehabilitation · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Ischemic stroke, one of the main public health problems worldwide, causes a variety of physiological dysfunction, including cognitive impairment. Although studies have been focused on posted-stroke cognitive impairment (PSCI), its pathological mechanism remains unclear. Methods: Here, we enrolled 66 participants stratified into three groups: healthy controls (HC, n=15), post-stroke patients without cognitive impairment (PSWCI, n=15), and PSCI patients (n=36). We analyzed clinical parameters and changes of several cytokines and gut microbiota profiles. Results: We found that compared with healthy control (HC) group, levels of low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), homocysteine (Hcy), CRP and IL-6 were significantly increased in PSWCI and PSCI patients. Of them, levels of Hcy and IL-6 in PSCI group were significantly higher than that in PSWCI. ROC curve analysis identified Hcy and IL-6 as potential diagnostic biomarkers for PSCI. Furthermore, 16S rRNA sequencing of gut microbiota shows that the abundance of Conclusion: These findings suggest that elevated Hcy and IL-6 levels may serve as risk factors for PSCI, with gut microbiota dysregulation potentially contributing to its pathogenesis.
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Registered trials
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