ReviewJournal of inflammation research2025
Pyroptosis in Pulpitis.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Redefining the Evolution of Pulpal Pathology: Inflammasomes as Central Integrative Hubs and Biological Switches Governing the Transition From Reversible to Irreversible Pulpal Inflammation Beyond Symptom-Based Classification.International endodontic journal · 2026Review
- Dysregulation of miR-140-3p is involved in the pathogenesis of pulpitis via the regulation of ACSL1.Odontology · 2026Article
- Decoding the molecular mechanisms of pyroptosis and its therapeutic development prospects.Frontiers in cell and developmental biology · 2026Review
- EZH2-Mediated Epigenetic Modifications Induce Pyroptosis in Dental Pulp Endothelial Cells via Activation of NLRP6 Inflammasome During Pulpitis Development.Mediators of inflammation · 2026Article
- Application of the Er:YAG laser in pulpotomy for mature permanent teeth with pulpitis: An animal study.PloS one · 2026Article
- Cuproptosis: a novel therapeutic mechanism in lung cancer.Cancer cell international · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulpitis is an inflammatory disease occurs in the pulp tissues. Continuous development of pulpitis can lead to apical periodontitis and seriously damage the function of teeth, affecting the oral health and daily life of patients. Pyroptosis, alternatively termed inflammatory necrosis, is a type of programmed cell death that is characterized by the swelling of cells until the cell membrane is broken. The GSDM family of proteins can be activated by a variety of pathways, which can lead to the puncture of cell membrane, inducing the release of cellular contents and inflammatory cytokines like IL-1β and IL-18 to activate a strong inflammatory response. Pyroptosis in dental pulp may be an important direction to find new targets for pulpal inflammation prevention and treatment, which deserves further study. In this article, we reviewed the activation mechanism and potential role of pyroptosis in the progression of pulpitis, along with the interaction between pyroptosis and other regulated cell death (RCD) pathways. This review aims to enrich the mechanism under the development of dental pulp inflammation, and to uncover potential therapeutic targets for early alleviation and treatment of pulp inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.