ArticleCureus2025
Treating Severe Primary Hypothyroidism: Turning Growth Failure Into Rapidly Progressive Puberty.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth failure and precocious or rapidly progressive puberty have been documented in several instances of untreated overt primary hypothyroidism. However, the sequential occurrence of these conditions within the same patient is less frequently observed. In this report, we present a case wherein growth failure, followed by rapidly progressive puberty, manifested following thyroxine replacement therapy. Notably, the etiology of the puberty onset in this case was centrally derived, distinguishing it from the more commonly reported Van Wyk-Grumbach syndrome. This case report provides a comprehensive summary of the aforementioned case, conducts a thorough review of relevant literature, and proposes a plausible mechanistic explanation for the observed association with gonadotropin-inhibiting hormones. The significance of maintaining vigilant thyroid function screening to detect non-specific or atypical presentations of hypothyroidism is also underscored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.