ArticleCureus2025
Recurrent Secondary Spontaneous Pneumothorax Due to Rheumatoid Arthritis: A Report of a Rare Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Secondary spontaneous pneumothorax is typically caused by tuberculosis or emphysema. Other causes include interstitial lung disease, pneumoconiosis, organizing pneumonias, and rare conditions like Langerhans cell histiocytosis and lymphangiomyomatosis. Rheumatoid arthritis is an uncommon cause of recurrent secondary spontaneous pneumothorax due to the rupture of subpleural necrobiotic nodules. Drugs like methotrexate and leflunomide are known to accelerate the development and progression of these necrobiotic nodules. Although the exact mechanism is unknown, it is believed to result from decreased monocyte activity and increased rheumatoid factor, with macrophages acting as a nidus that interacts with rheumatoid factor to form a nodule, ultimately leading to pneumothorax when it communicates with the pleural space. This report presents a rare case of recurrent spontaneous pneumothorax resulting from the rupture of subpleural necrobiotic nodules in a patient with rheumatoid arthritis-associated lung disease.
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