ArticleCureus2025
Soluble Receptor of Advanced Glycation End Products and Cardiometabolic Markers in Children.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Oxidative Stress, Antioxidant Cofactor Micronutrients, and Cognitive Outcomes in Childhood Obesity: Mechanisms, Evidence, and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The soluble receptor for advanced glycation end products (sRAGE) is a proposed obesity biomarker, but its role in childhood has not been fully elucidated. This study aimed to evaluate the association between sRAGE levels and cardiometabolic factors in children according to body mass index (BMI). Introduction This cross-sectional study included 124 children aged 6-9 years, categorized as normal weight (n=72) and overweight or with obesity (n=52). Anthropometric and clinical measurements included weight, height, BMI, waist circumference (WC), neck circumference, and systolic and diastolic blood pressure (SBP and DBP). Fasting blood samples were collected to measure glucose, lipid profile, uric acid (UA), and sRAGE levels using standardized methods. We also calculated the triglyceride-glucose index (TyG), visceral adiposity index (VAI), and triglyceride-to-HDL-C (TG:HDL-C) ratio. Results Children who were overweight and obese exhibited lower sRAGE levels compared to the normal-weight group (p= 0.02) and higher WC, NC, UA, HDL-C, TG, SBP, DBP, TyG, TG:HDL-C ratio, and VAI than the normal-weight group (p<0.01). No differences in glucose, creatinine, and cholesterol were found. Finally, sRAGE levels showed correlations with BMI (r=-0.358, p=0.03), WC (r=-0.242, p=0.00), and HDL-cholesterol (r=0.207, p=0.01). Conclusions Children with obesity presented lower sRAGE levels and higher cardiometabolic risk markers, including higher WC, TG, TG: HDL-C ratio, TyG index, VAI score, and lower HDL-C than the normal weight group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.