Evidence map›Paper›PMID 40322275›Full record

ArticleClinical pharmacology : advances and applications2025

A Case Report of Sustained Cytokine Release Syndrome Due to Glofitamab and Literature Review.

Jingyi Yang, Qian Shen, Xiaoyan Ke, Wei Liu, Ping Yang

Abstract readCase Reports
In one paragraph

Article in Clinical pharmacology : advances and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingyi Yang *Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, People's Republic of China.ORCID 0009-0008-6721-8852
Qian Shen *Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Xiaoyan KeDepartment of Hematology, Peking University Third Hospital, Beijing, 100191, People's Republic of China.
Wei LiuDepartment of Pharmacy, Peking University Third Hospital, Beijing, 100191, People's Republic of China.ORCID 0000-0002-1773-5156
Ping YangDepartment of Hematology, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glofitamab is a novel bispecific antibody targeting CD20×CD3, capable of simultaneously targeting CD20 and CD3 to activate T cells and release cytotoxic proteins that kill cancer cells. Cytokine release syndrome (CRS) is one of the most common adverse events observed in clinical trials of glofitamab. In most cases, CRS is mild, transient, and manageable with appropriate treatment. This paper reports a case of persistent CRS in a patient with mantle cell lymphoma following glofitamab treatment and reviews the relevant literature for reference.

Indexed as

cytokine release syndromecytokinesglofitamabinterleukin-6

Identifiers

PMID40322275
PMCPMC12049670

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.